Gene
ctsf
- ID
- ZDB-GENE-030131-9831
- Name
- cathepsin F
- Symbol
- ctsf Nomenclature History
- Previous Names
-
- cb420 (1)
- sb:cb420
- zgc:153093
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm; endomembrane system; and intracellular organelle lumen. Predicted to be active in extracellular space and lysosome. Is expressed in mesoderm; nervous system; neural tube; solid lens vesicle; and ventral mesenchyme. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 13. Orthologous to human CTSF (cathepsin F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb420 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neuronal ceroid lipofuscinosis 13 | Alliance | Ceroid lipofuscinosis, neuronal, 13 (Kufs type) | 615362 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Domain | IPR000010 | Cystatin domain |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
| Homologous_superfamily | IPR046350 | Cystatin superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cathepsin propeptide inhibitor domain (I29) | Cystatin domain | Cystatin superfamily | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08CH0 | InterPro | 473 | |||||||||
| UniProtKB:F1RE14 | InterPro | 473 |
Interactions and Pathways
No data available
Plasmids
No data available