Gene
lama5
- ID
- ZDB-GENE-030131-9823
- Name
- laminin, alpha 5
- Symbol
- lama5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including cell-cell adhesion; fin morphogenesis; and regulation of basement membrane organization. Predicted to be located in extracellular region and synapse. Predicted to be part of laminin-10 complex. Predicted to be active in basement membrane. Is expressed in several structures, including axial mesoderm; nervous system; pectoral fin bud; pericardial region; and pharynx. Human ortholog(s) of this gene implicated in bent bone dysplasia syndrome 2 and familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb402 (39 images)
- IMAGE:7138247 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| gyf46 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | not specified | |
| gyf47 | Allele with one deletion | Exon 2 | Unknown | not specified | |
| la022827Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022828Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m538 | Allele with one point mutation | Exon 59 | Premature Stop | ENU | |
| sa6725 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9446 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9662 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13881 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16078 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| bent bone dysplasia syndrome 2 | Alliance | ?Bent bone dysplasia syndrome 2 | 620076 |
| Nephrotic syndrome, type 26 | 620049 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like domain | Laminin alpha, domain I | Laminin domain II | Laminin G domain | Laminin IV | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AY57 | InterPro | 3662 | |||||||||
| UniProtKB:A0A8M3ANE8 | InterPro | 3665 | |||||||||
| UniProtKB:Q2Q1W5 | InterPro | 3664 | |||||||||
| UniProtKB:A0AB32TDI7 | InterPro | 3661 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-78G5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-14P11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-204F1 | ZFIN Curated Data | |
| Encodes | EST | cb402 | Thisse et al., 2001 | |
| Encodes | EST | fb81a10 | Rauch et al., 2003 | |
| Encodes | EST | IMAGE:7138247 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039171 (1) | 11565 nt | ||
| Genomic | GenBank:CR388032 (1) | 271754 nt | ||
| Polypeptide | UniProtKB:A0A8M3ANE8 (1) | 3665 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zhu, M., Li, Y., Liu, D., Gong, Z. (2024) Partial Hepatectomy Promotes the Development of KRASG12V-Induced Hepatocellular Carcinoma in Zebrafish. Cancers. 16(10):
- Benard, E.L., Küçükaylak, I., Hatzold, J., Berendes, K.U.W., Carney, T.J., Beleggia, F., Hammerschmidt, M. (2023) wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(6):566-592
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Jayadev, R., Morais, M.R.P.T., Ellingford, J.M., Srinivasan, S., Naylor, R.W., Lawless, C., Li, A.S., Ingham, J.F., Hastie, E., Chi, Q., Fresquet, M., Koudis, N.M., Thomas, H.B., O'Keefe, R.T., Williams, E., Adamson, A., Stuart, H.M., Banka, S., Smedley, D., Genomics England Research Consortium, Sherwood, D.R., Lennon, R. (2022) A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations. Science advances. 8:eabn2265
- Naylor, R.W., Watson, E., Williamson, S., Preston, R., Davenport, J.B., Thornton, N., Lowe, M., Williams, M., Lennon, R. (2022) Basement membrane defects in CD151-associated glomerular disease. Pediatric nephrology (Berlin, Germany). 37(12):3105-3115
- Zhao, N., Wang, X., Wang, T., Xu, X., Liu, Q., Li, J. (2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). International Journal of Molecular Sciences. 23(18)
- Derrick, C.J., Pollitt, E.J.G., Sevilla Uruchurtu, A.S., Hussein, F., Grierson, A.J., Noël, E.S. (2021) Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development. Development (Cambridge, England). 148(20)
- Armistead, J., Hatzold, J., van Roye, A., Fahle, E., Hammerschmidt, M. (2020) Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase. The Journal of cell biology. 219(2):
- Mukherjee, D., Wagh, G., Mokalled, M.H., Kontarakis, Z., Dickson, A.L., Rayrikar, A., Günther, S., Poss, K.D., Stainier, D.Y.R., Patra, C. (2020) Ccn2a/Ctgfa is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. Development (Cambridge, England). 148(2):
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