Gene
tomm22
- ID
- ZDB-GENE-030131-9810
- Name
- translocase of outer mitochondrial membrane 22 homolog (yeast)
- Symbol
- tomm22 Nomenclature History
- Previous Names
-
- oli
- cb381 (1)
- sb:cb381
- zgc:86742
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to contribute to protein transmembrane transporter activity. Acts upstream of or within liver development. Predicted to be located in mitochondrial outer membrane. Predicted to be part of mitochondrial outer membrane translocase complex. Is expressed in EVL; digestive system; epidermis; notochord; and periderm. Orthologous to human TOMM22 (translocase of outer mitochondrial membrane 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb381 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| s469 | Allele with one point mutation | Unknown | Missense | not specified |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR005683 | Mitochondrial import receptor subunit Tom22 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Mitochondrial import receptor subunit Tom22 |
|---|---|---|---|
| UniProtKB:Q6IQJ1 | InterPro | 134 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tomm22-201
(1)
|
Ensembl | 1,241 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16I5 | ZFIN Curated Data | |
| Encodes | EST | cb381 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:86742 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173879 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173880 | ZFIN Curated Data | |
| Has Artifact | EST | fa02g11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001724 (1) | 1267 nt | ||
| Genomic | GenBank:BX649366 (2) | 222310 nt | ||
| Polypeptide | UniProtKB:Q6IQJ1 (1) | 134 aa |
- Shi, D., Qi, M., Zhou, L., Li, X., Ni, L., Li, C., Yuan, T., Wang, Y., Chen, Y., Hu, C., Liang, D., Li, L., Liu, Y., Li, J., Chen, Y.H. (2018) Endothelial Mitochondrial Preprotein Translocase Tomm7-Rac1 Signaling Axis Dominates Cerebrovascular Network Homeostasis. Arteriosclerosis, Thrombosis, and Vascular Biology. 38:2665-2677
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wu, J., Choi, T.Y., Shin, D. (2017) tomm22 Knockdown-Mediated Hepatocyte Damages Elicit Both the Formation of Hybrid Hepatocytes and Biliary Conversion to Hepatocytes in Zebrafish Larvae.. Gene Expression. 17(3):237-249
- Palha, N., Guivel-Benhassine, F., Briolat, V., Lutfalla, G., Sourisseau, M., Ellett, F., Wang, C.H., Lieschke, G.J., Herbomel, P., Schwartz, O., and Levraud, J.P. (2013) Real-time whole-body visualization of chikungunya virus infection and host interferon response in zebrafish. PLoS pathogens. 9(9):e1003619
- Curado, S., Ober, E.A., Walsh, S., Cortes-Hernandez, P., Verkade, H., Koehler, C.M., and Stainier, D.Y. (2010) The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. Disease models & mechanisms. 3(7-8):486-495
- Ozbudak, E.M., Tassy, O., and Pourquié, O. (2010) Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Proceedings of the National Academy of Sciences of the United States of America. 107(9):4224-4229
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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