Gene

paics

ID
ZDB-GENE-030131-9762
Name
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Symbol
paics Nomenclature History
Previous Names
  • cb293 (1)
  • multifunctional protein ADE2 (1)
  • sb:cb293
  • wu:fa28a05
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Acts upstream of or within chordate embryonic development; pigmentation; and retina development in camera-type eye. Is expressed in several structures, including eye; immature eye; midbrain; neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hi2688TgTransgenic insertion5' UTRUnknownDNA
sa892Allele with one point mutationUnknownSplice SiteENU
sa4900Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With paics Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Phosphoribosylaminoimidazole carboxylase deficiency 619859
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Associated With paics Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018236 SAICAR synthetase, conserved site
Domain IPR000031 PurE domain
Domain IPR028923 SAICAR synthetase/ADE2, N-terminal
Domain IPR033626 Class II PurE
Domain IPR044822 Myb/SANT-like DNA-binding domain 4
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Domain Details Per Protein
Protein Additional Resources Length Class II PurE Myb/SANT-like DNA-binding domain 4 PurE domain SAICAR synthetase SAICAR synthetase/ADE2, N-terminal SAICAR synthetase, conserved site
UniProtKB:Q7ZUN6 InterPro 425
UniProtKB:A0AB32TF25 InterPro 1042
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA paics-201 (1) Ensembl 3,362 nt
mRNA paics-202 (1) Ensembl 1,565 nt
mRNA paics-203 (1) Ensembl 1,720 nt
mRNA paics-204 (1) Ensembl 1,923 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPAICS4
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Nucleotide sequence comparison (1)
MousePaics5
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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