Gene
smarce1
- ID
- ZDB-GENE-030131-967
- Name
- SWI/SNF related BAF chromatin remodeling complex subunit E1
- Symbol
- smarce1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable nuclear receptor binding activity. Acts upstream of or within endocardium morphogenesis and iridophore differentiation. Predicted to be located in nucleus. Predicted to be part of SWI/SNF complex. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 5; familial meningioma; and meningioma. Orthologous to human SMARCE1 (SWI/SNF related BAF chromatin remodeling complex subunit E1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55303 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa12524 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12565 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18758 | unknown | Unknown | Unknown | ENU | |
sa20071 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33229 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
una1 | Allele with one deletion | Unknown | Unknown | CRISPR | |
una2 | Allele with one deletion | Unknown | Unknown | CRISPR |
1 - 7 of 7
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-smarce1 | (2) | |
CRISPR2-smarce1 | (2) | |
CRISPR3-smarce1 | (2) | |
CRISPR4-smarce1 | (2) | |
CRISPR5-smarce1 | (2) | |
CRISPR6-smarce1 | (2) | |
CRISPR7-smarce1 | (2) | |
CRISPR8-smarce1 | (2) | |
CRISPR9-smarce1 | (2) | |
CRISPR10-smarce1 | (2) |
1 - 10 of 12
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Coffin-Siris syndrome 5 | Alliance | Coffin-Siris syndrome 5 | 616938 |
{Meningioma, familial, susceptibility to} | 607174 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily |
---|---|---|---|---|
UniProtKB:A0A8M2BBH2 | InterPro | 422 | ||
UniProtKB:A0A8M9PJR1 | InterPro | 391 | ||
UniProtKB:A0A8M9P4E1 | InterPro | 387 | ||
UniProtKB:A0A8M3AQX7 | InterPro | 424 | ||
UniProtKB:Q803S1 | InterPro | 420 |
1 - 5 of 6 Show all
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
smarce1-201
(1)
|
Ensembl | 1,995 nt | ||
mRNA |
smarce1-202
(1)
|
Ensembl | 2,072 nt | ||
mRNA |
smarce1-203
(1)
|
Ensembl | 1,263 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-15H19 | ZFIN Curated Data | |
Encodes | EST | fb33d02 | ||
Encodes | EST | fb54d11 | ||
Encodes | cDNA | MGC:55303 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77275 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191900 | ZFIN Curated Data |
1 - 6 of 6
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201298 (1) | 2062 nt | ||
Genomic | GenBank:BX890590 (1) | 141661 nt | ||
Polypeptide | UniProtKB:A0A8M2BB53 (1) | 426 aa |
- Tang, C.Y., Zhang, X., Xu, X., Sun, S., Peng, C., Song, M.H., Yan, C., Sun, H., Liu, M., Xie, L., Luo, S.J., Li, J.T. (2023) Genetic mapping and molecular mechanism behind color variation in the Asian vine snake. Genome biology. 24:4646
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Schnabel, D., Castillo-Robles, J., Lomeli, H. (2019) Protein Purification and Western Blot Detection from Single Zebrafish Embryo. Zebrafish. 16(6):505-507
- Castillo-Robles, J., Ramírez, L., Spaink, H.P., Lomelí, H. (2018) smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish. Scientific Reports. 8:15369
- Li, Z., Long, Y., Zhong, L., Song, G., Zhang, X., Yuan, L., Cui, Z., Dai, H. (2016) RNA sequencing provides insights into the toxicogenomic response of ZF4 cells to methyl methanesulfonate. Journal of applied toxicology : JAT. 36(1):94-104
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Long, Y., Yan, J., Song, G., Li, X., Li, X., Li, Q., Cui, Z. (2015) Transcriptional events co-regulated by hypoxia and cold stresses in Zebrafish larvae. BMC Genomics. 16:385
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
1 - 10 of 13
Show