Gene
lyve1b
- ID
- ZDB-GENE-030131-9516
- Name
- lymphatic vessel endothelial hyaluronic receptor 1b
- Symbol
- lyve1b Nomenclature History
- Previous Names
-
- lyve-1 (1)
- lyve1
- lyve1l
- fj84c10
- si:dkey-5a9.3
- wu:fj84c10
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable hyaluronic acid binding activity and transmembrane signaling receptor activity. Predicted to be active in plasma membrane. Is expressed in brain; cardiovascular system; horizontal myoseptum; pharynx; and trunk. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lyve1b-201
(1)
|
Ensembl | 861 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(lyve1b:Kaede) |
|
| 1 | Eng et al., 2019 | |
| Tg(-5.2lyve1b:DsRed) |
|
| 2 | (65) | |
| Tg(-5.2lyve1b:EGFP) |
|
| 1 | (15) | |
| Tg(-5.2lyve1b:Venus) |
|
| 1 | Arnold et al., 2022 | |
| Tg(lyve1b:BFP-CAAX,cryaa:EGFP) |
|
| 1 | Bower et al., 2017 | |
| Tg(lyve1b:CreERT2) |
|
| 1 | (3) | |
| Tg(lyve1b:egfl7-2A-GFP) |
|
| 1 | Chen et al., 2024 | |
| Tg(lyve1b:f2r-2A-mCherry) |
|
| 1 | Lei et al., 2021 | |
| Tg(lyve1b:GFP) |
|
| 1 | (2) | |
| Tg(lyve1b:Kaede) |
|
| 1 | Chen et al., 2019 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:GDQH01022136 (1) | 1336 nt | ||
| Genomic | GenBank:BX571951 | 157583 nt |
- Chen, J., Ding, J., Li, Y., Feng, F., Xu, Y., Wang, T., He, J., Cang, J., Luo, L. (2024) Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3. Nature communications. 15:59865986
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Gafranek, J.T., D'Aniello, E., Ravisankar, P., Thakkar, K., Vagnozzi, R.J., Lim, H.W., Salomonis, N., Waxman, J.S. (2023) Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature communications. 14:55095509
- Arnold, H., Panara, V., Hußmann, M., Filipek-Gorniok, B., Skoczylas, R., Ranefall, P., Gloger, M., Allalou, A., Hogan, B.M., Schulte-Merker, S., Koltowska, K. (2022) mafba and mafbb differentially regulate lymphatic endothelial cell migration in topographically distinct manners. Cell Reports. 39:110982
- Britto, D.D., He, J., Misa, J.P., Chen, W., Kakadia, P.M., Grimm, L., Herbert, C.D., Crosier, K.E., Crosier, P.S., Bohlander, S.K., Hogan, B.M., Hall, C.J., Torres-Vázquez, J., Astin, J.W. (2022) Plexind1 negatively regulates zebrafish lymphatic development. Development (Cambridge, England). 149(21)
- Das, R.N., Tevet, Y., Safriel, S., Han, Y., Moshe, N., Lambiase, G., Bassi, I., Nicenboim, J., Brückner, M., Hirsch, D., Eilam-Altstadter, R., Herzog, W., Avraham, R., Poss, K.D., Yaniv, K. (2022) Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 606(7914):570-575
- Gurung, S., Restrepo, N.K., Chestnut, B., Klimkaite, L., Sumanas, S. (2022) Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos. Scientific Reports. 12:13065
- Peng, D., Ando, K., Hußmann, M., Gloger, M., Skoczylas, R., Mochizuki, N., Betsholtz, C., Fukuhara, S., Schulte-Merker, S., Lawson, N.D., Koltowska, K. (2022) Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells. eLIFE. 11
- Peng, L., Ma, M., Dong, Y., Wu, Q., An, S., Cao, M., Wang, Y., Zhou, C., Zhou, M., Wang, X., Liang, Q., Wang, Y. (2022) Kuoxin Decoction promotes lymphangiogenesis in zebrafish and in vitro based on network analysis. Frontiers in pharmacology. 13:915161
- Chen, J., Li, X., Ni, R., Chen, Q., Yang, Q., He, J., Luo, L. (2021) Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell. 56(22):3115-3127.e6
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