Gene
lamp1b
- ID
- ZDB-GENE-030131-9303
- Name
- lysosomal associated membrane protein 1b
- Symbol
- lamp1b Nomenclature History
- Previous Names
-
- lamp1
- fa56f11
- si:ch211-218d20.14
- wu:fa56f11
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to be involved in establishment of protein localization to organelle. Predicted to be located in endosome membrane and lysosome. Predicted to be active in late endosome membrane; lysosomal membrane; and plasma membrane. Is expressed in several structures, including eye; heart; liver; muscle; and notochord. Orthologous to human LAMP1 (lysosomal associated membrane protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Lysosome-associated membrane glycoprotein | Lysosome-associated membrane glycoprotein 2-like, luminal domains | Lysosome-associated membrane glycoprotein 2-like, transmembrane domain |
|---|---|---|---|---|---|
| UniProtKB:E9QCP4 | InterPro | 253 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lamp1b-201
(1)
|
Ensembl | 2,333 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-4.9sox10:lamp1b-GFP,myl7:EGFP) |
| 1 | Zhu et al., 2019 | ||
| Tg(hsp70l:lamp1b-RFP) |
|
| 2 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218D20 | ZFIN Curated Data | |
| Encodes | EST | fa56f11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001326532 (1) | 2345 nt | ||
| Genomic | GenBank:BX294189 (1) | 194025 nt | ||
| Polypeptide | UniProtKB:E9QCP4 (1) | 253 aa |
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Lee, J.J., Wang, T., Wiggins, K., Lu, P.N., Underwood, C., Ochenkowska, K., Samarut, E., Pollard, L.M., Flanagan-Steet, H., Steet, R. (2024) Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders. iScience. 27:109293109293
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Iyer, H., Shen, K., Meireles, A.M., Talbot, W.S. (2022) A lysosomal regulatory circuit essential for the development and function of microglia. Science advances. 8:eabp8321
- Han, S.L., Qian, Y.C., Limbu, S.M., Wang, J., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2021) Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(9):158988
- Ikeda, A., Komamizu, M., Hayashi, A., Yamasaki, C., Okada, K., Kawabe, M., Komatsu, M., Shiozaki, K. (2021) Neu1 deficiency induces abnormal emotional behavior in zebrafish. Scientific Reports. 11:13477
- Kim, M., Lu, L., Dvornikov, A.V., Ma, X., Ding, Y., Zhu, P., Olson, T.M., Lin, X., Xu, X. (2021) TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy. International Journal of Molecular Sciences. 22(11):
- Yu, S.H., Wang, T., Wiggins, K., Louie, R.J., Merino, E.F., Skinner, C., Cassera, M.B., Meagher, K., Goldberg, P., Rismanchi, N., Chen, D., Lyons, M.J., Flanagan-Steet, H., Steet, R. (2021) Lysosomal cholesterol accumulation contributes to the movement phenotypes associated with NUS1 haploinsufficiency. Genetics in medicine : official journal of the American College of Medical Genetics. 23(7):1305-1314
- Ji, X., Jiang, P., Luo, J., Li, M., Bai, Y., Zhang, J., Han, B. (2020) Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cells. PLoS One. 15:e0226905
- Lescat, L., Véron, V., Mourot, B., Péron, S., Chenais, N., Dias, K., Riera, N., Beaumatin, F., Pinel, K., Priault, M., Panserat, S., Salin, B., Guiguen, Y., Bobe, J., Herpin, A., Seiliez, I. (2020) Chaperone-Mediated Autophagy in the light of evolution: insight from fish. Molecular Biology and Evolution. 37(10):2887-2899
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