Gene
timeless
- ID
- ZDB-GENE-030131-8978
- Name
- timeless circadian clock
- Symbol
- timeless Nomenclature History
- Previous Names
-
- Tim (1)
- fa95g04
- fd23d07
- im:6903167
- wu:fa95g04
- wu:fd23d07
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Predicted to be involved in DNA repair; DNA replication checkpoint signaling; and replication fork arrest. Predicted to be located in nucleus. Predicted to be part of replication fork protection complex. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome 4 and alcohol use disorder. Orthologous to human TIMELESS (timeless circadian regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903167 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15256 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18131 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21833 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35005 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| advanced sleep phase syndrome 4 | Alliance | ?Advance sleep phase syndrome, familial, 4 | 620015 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Timeless | Timeless, C-terminal | Timeless, N-terminal |
|---|---|---|---|---|---|
| UniProtKB:E7FGL0 | InterPro | 1278 | |||
| UniProtKB:A0A2R8Q1Y3 | InterPro | 1239 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
timeless-201
(1)
|
Ensembl | 4,416 nt | ||
| mRNA |
timeless-202
(1)
|
Ensembl | 712 nt | ||
| mRNA |
timeless-203
(1)
|
Ensembl | 3,959 nt | ||
| mRNA |
timeless-204
(1)
|
Ensembl | 3,962 nt | ||
| mRNA |
timeless-205
(1)
|
Ensembl | 4,142 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-257J20 | ZFIN Curated Data | |
| Encodes | EST | fa95g04 | ||
| Encodes | EST | fd23d07 | ||
| Encodes | EST | IMAGE:6903167 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001278600 (1) | 4540 nt | ||
| Genomic | GenBank:AL954313 (1) | 156381 nt | ||
| Polypeptide | UniProtKB:E7FGL0 (1) | 1278 aa |
- Zheng, X., Zhang, K., Zhao, Y., Fent, K. (2021) Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans. Environment International. 149:106159
- Manesia, J.K., Franch, M., Tabas-Madrid, D., Nogales-Cadenas, R., Vanwelden, T., Van Den Bosch, E., Xu, Z., Pascual-Montano, A., Khurana, S., Verfaillie, C. (2017) Distinct molecular signature of murine fetal liver and adult hematopoietic stem cells identifies novel regulators of hematopoietic stem cell function. Stem cells and development. 26(8):573-584
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Toloza-Villalobos, J., Arroyo, J.I., Opazo, J.C. (2015) The Circadian Clock of Teleost Fish: A Comparative Analysis Reveals Distinct Fates for Duplicated Genes. Journal of molecular evolution. 80(1):57-64
- Zhao, Y., Castiglioni, S., Fent, K. (2015) Environmental progestins progesterone and drospirenone alter the circadian rhythm network in zebrafish (Danio rerio). Environmental science & technology. 49(16):10155-64
- Kopp, R., Schwerte, T., Egg, M., Sandbichler, A.M., Egger, B., and Pelster, B. (2010) Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. Physiological Genomics. 42(1):8-23
- Pando, M.P. and Sassone-Corsi, P. (2002) Unraveling the mechanisms of the vertebrate circadian clock: zebrafish may light the way. BioEssays : news and reviews in molecular, cellular and developmental biology. 24(5):419-426
- Whitmore, D., Foulkes, N.S., and Sassone-Corsi, P. (2000) Light acts directly on organs and cells in culture to set the vertebrate circadian clock. Nature. 404(6773):87-91
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