Gene
plxnb2a.1
- ID
- ZDB-GENE-030131-8917
- Name
- plexin b2a, tandem duplicate 1
- Symbol
- plxnb2a.1 Nomenclature History
- Previous Names
-
- fk37b01
- plxnb2a
- im:7054697
- si:dkey-261e22.2
- wu:fk37b01
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable semaphorin receptor activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Is expressed in head; nervous system; otic vesicle; pectoral fin; and trunk. Orthologous to human PLXNB2 (plexin B2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Lamont et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa839 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6933 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa6934 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17574 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20240 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-plxnb2a.1 | N/A | Lamont et al., 2009 |
| MO2-plxnb2a.1 | N/A | Lamont et al., 2009 |
| MO3-plxnb2a.1 | N/A | Perälä et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin, cytoplasmic RasGAP domain | Plexin, cytoplasmic RhoGTPase-binding domain | Plexin family | Plexin repeat | Plexin, TIG domain 1 | PSI domain | Rho GTPase activation protein | Sema domain | Sema domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:C5H5I1 | InterPro | 1864 | |||||||||||||
| UniProtKB:F1QBC0 | InterPro | 1864 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
plxnb2a-201
(1)
|
Ensembl | 5,760 nt | ||
| mRNA |
plxnb2a-202
(1)
|
Ensembl | 4,473 nt | ||
| mRNA |
plxnb2a-203
(1)
|
Ensembl | 5,805 nt | ||
| mRNA |
plxnb2a-204
(1)
|
Ensembl | 5,676 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-261E22 | ZFIN Curated Data | |
| Encodes | EST | fk37b01 | ||
| Encodes | EST | IMAGE:7054697 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161600 (1) | 5595 nt | ||
| Genomic | GenBank:BX323886 (1) | 158224 nt | ||
| Polypeptide | UniProtKB:C5H5I1 (1) | 1864 aa |
- Comparative Orthology
- Alliance
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Mazzolini, J., Le Clerc, S., Morisse, G., Coulonges, C., Kuil, L.E., van Ham, T.J., Zagury, J.F., Sieger, D. (2019) Gene expression profiling reveals a conserved microglia signature in larval zebrafish. Glia. 68(2):298-315
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Babaei, F., Ramalingam, R., Tavendale, A., Liang, Y., Yan, L.S., Ajuh, P., Cheng, S.H., and Lam, Y.W. (2013) Novel Blood Collection Method Allows Plasma Proteome Analysis from Single Zebrafish. Journal of Proteome Research. 12(4):1580-90
- Perälä, N., Peitsaro, N., Sundvik, M., Koivula, H., Sainio, K., Sariola, H., Panula, P., and Immonen, T. (2010) Conservation, expression, and knockdown of zebrafish plxnb2a and plxnb2b. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2722-2734
- Lamont, R.E., Lamont, E.J., and Childs, S.J. (2009) Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation. Developmental Biology. 331(2):199-209
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