Gene
ptx3a
- ID
- ZDB-GENE-030131-8720
- Name
- pentraxin 3, long a
- Symbol
- ptx3a Nomenclature History
- Previous Names
-
- fb05a06
- sb:eu1077
- si:ch211-272f3.3
- wu:fb05a06
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable complement component C1q complex binding activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within immune response. Predicted to be active in extracellular space. Is expressed in several structures, including epidermis; fin; hypochord; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1077 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ptx3a | Xia et al., 2022 | |
| CRISPR2-ptx3a | Xia et al., 2022 | |
| CRISPR3-ptx3a | Lu et al., 2023 | |
| CRISPR4-ptx3a | Lu et al., 2023 | |
| CRISPR5-ptx3a | Lu et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | Pentaxin, conserved site | Pentraxin-related | Pentraxin-related protein PTX3 |
|---|---|---|---|---|---|---|
| UniProtKB:A3KPN4 | InterPro | 447 | ||||
| UniProtKB:A3KPN2 | InterPro | 447 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(ptx3a:Cre-ERT2,cryaa:RFP) |
|
| 1 | Xia et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-232P17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-272F3 | ZFIN Curated Data | |
| Encodes | EST | eu1077 | Thisse et al., 2005 | |
| Encodes | EST | fb05a06 | ||
| Encodes | EST | fb04g11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021473342 (1) | 5102 nt | ||
| Genomic | GenBank:BX255879 (1) | 173755 nt | ||
| Polypeptide | UniProtKB:A3KPN2 (2) | 447 aa |
- Lu, F., Leach, L.L., Gross, J.M. (2023) A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports. 13:31423142
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
- Guerra, J., Chiodelli, P., Tobia, C., Gerri, C., Presta, M. (2020) Long-Pentraxin 3 Affects Primary Cilium in Zebrafish Embryo and Cancer Cells via the FGF System. Cancers. 12(7):
- Guerra, A., Germano, R.F., Stone, O., Arnaout, R., Guenther, S., Ahuja, S., Uribe, V., Vanhollebeke, B., Stainier, D.Y., Reischauer, S. (2018) Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. eLIFE. 7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Steiner, A.B., Kim, T., Cabot, V., Hudspeth, A.J. (2014) Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line. Proceedings of the National Academy of Sciences of the United States of America. 111:E1393-401
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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