Gene
irs1
- ID
- ZDB-GENE-030131-872
- Name
- insulin receptor substrate 1
- Symbol
- irs1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Acts upstream of or within cellular response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including digestive system; endocrine system; kidney; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Kamei et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-irs1 | Zebrafish Nomenclature Committee | |
CRISPR2-irs1 | Mazzaferro et al., 2025 | |
MO1-irs1 | N/A | O'Hare et al., 2016 |
MO2-irs1 | N/A | Kamei et al., 2018 |
1 - 4 of 4
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus, susceptibility to} | 125853 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
---|---|---|---|---|---|---|
UniProtKB:E7F4P8 | InterPro | 1099 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-287E13 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-51H1 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-110B2 | ZFIN Curated Data | |
Encodes | EST | fb51f11 | ||
Encodes | EST | fd14h02 |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_682610 (1) | 5745 nt | ||
Genomic | GenBank:CR854907 (1) | 187961 nt | ||
Polypeptide | UniProtKB:E7F4P8 (1) | 1099 aa |
- Mazzaferro, E., Mujica, E., Zhang, H., Emmanouilidou, A., Jenseit, A., Evcimen, B., Metzendorf, C., Dethlefsen, O., Loos, R.J., Vienberg, S.G., Larsson, A., Allalou, A., den Hoed, M. (2025) Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning. Scientific Reports. 15:54085408
- Ulhaq, Z.S., Tse, W.K.F. (2024) PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease. Genes. 15(1):
- Yu, W., Luo, R., He, C., Li, Z., Yang, M., Zhou, J., He, J., Chen, Q., Song, Z., Cheng, S. (2024) Bergenin mitigates neuroinflammatory damage induced by high glucose: insights from Zebrafish, murine microbial cell line, and rat models. Frontiers in pharmacology. 15:13391781339178
- Li, X., Zhou, L., Zheng, Y., He, T., Guo, H., Li, J., Zhang, J. (2023) Establishment of a non-alcoholic fatty liver disease model by high fat diet in adult zebrafish. Animal models and experimental medicine. 7(6):904-913
- Qian, X., Klatt, S., Bennewitz, K., Wohlfart, D.P., Lou, B., Meng, Y., Buettner, M., Poschet, G., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Fleming, I., Szendroedi, J., Nawroth, P.P., Kroll, J. (2023) Impaired Detoxification of Trans, Trans-2,4-Decadienal, an Oxidation Product from Omega-6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(4):e2302325
- Thakuri, L.S., Park, C.M., Park, J.W., Rhyu, D.Y. (2023) Gracilaria chorda subcritical-water extracts as ameliorant of insulin resistance induced by high-glucose in zebrafish and dexamethasone in L6 myotubes. Journal of traditional and complementary medicine. 14:829082-90
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Shao, R., Liao, X., Lan, Y., Zhang, H., Jiao, L., Du, Q., Han, D., Ai, Q., Mai, K., Wan, M. (2022) Vitamin D regulates insulin pathway and glucose metabolism in zebrafish (Danio rerio). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22330
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Knuth, M.M., Mahapatra, D., Jima, D., Wan, D., Hammock, B.D., Law, M., Kullman, S.W. (2020) Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Scientific Reports. 10:16032
1 - 10 of 24
Show