Gene

irs1

ID
ZDB-GENE-030131-872
Name
insulin receptor substrate 1
Symbol
irs1 Nomenclature History
Previous Names
  • fb51f11
  • fd14h02
  • si:dkeyp-51h1.1 (1)
  • wu:fb51f11 (1)
  • wu:fd14h02
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Acts upstream of or within cellular response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including digestive system; endocrine system; kidney; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Kamei et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb721Allele with one delinsExon 1UnknownCRISPR
sa35963Allele with one point mutationUnknownPremature StopENU
sa42600Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With irs1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 2 diabetes mellitus Alliance {Type 2 diabetes mellitus, susceptibility to} 125853
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Associated With irs1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001849 Pleckstrin homology domain
Domain IPR002404 IRS-type PTB domain
Family IPR039011 Insulin receptor substrate
Homologous_superfamily IPR011993 PH-like domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Insulin receptor substrate IRS-type PTB domain PH-like domain superfamily Pleckstrin homology domain
UniProtKB:E7F4P8 InterPro 1099
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA irs1-201 (1) Ensembl 8,274 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-287E13ZFIN Curated Data
Contained inBACDKEYP-51H1ZFIN Curated Data
Contained inBACDKEYP-110B2ZFIN Curated Data
EncodesESTfb51f11
EncodesESTfd14h02
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanIRS12
Phylogenetic tree (1)
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseIrs11
Amino acid sequence comparison (2)
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
Citations
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