Gene
rpl17
- ID
- ZDB-GENE-030131-8585
- Name
- ribosomal protein L17
- Symbol
- rpl17 Nomenclature History
- Previous Names
-
- fa91a06
- wu:fa91a06
- wu:fa99c06
- zgc:65996 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in cytosolic ribosome. Predicted to be part of cytosolic large ribosomal subunit. Orthologous to human RPL17 (ribosomal protein L17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018260 | Large ribosomal subunit protein uL22, conserved site |
| Family | IPR001063 | Large ribosomal subunit protein uL22 |
| Family | IPR005721 | Large ribosomal subunit protein uL22, eukaryotic/archaeal |
| Homologous_superfamily | IPR036394 | Ribosomal protein uL22 superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Large ribosomal subunit protein uL22 | Large ribosomal subunit protein uL22, conserved site | Large ribosomal subunit protein uL22, eukaryotic/archaeal | Ribosomal protein uL22 superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q7T1K0 | InterPro PDB | 184 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-203L7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-222N4 | ZFIN Curated Data | |
| Encodes | EST | fa91a06 | ||
| Encodes | EST | fa99c06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65996 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001319650 (1) | 804 nt | ||
| Genomic | GenBank:BX000991 (1) | 170966 nt | ||
| Polypeptide | UniProtKB:Q7T1K0 (1) | 184 aa |
- Comparative Orthology
- Alliance
- Fellmann, F., Saunders, C., O'Donohue, M.F., Reid, D.W., McFadden, K.A., Montel-Lehry, N., Yu, C., Fang, M., Zhang, J., Royer-Bertrand, B., Farinelli, P., Karboul, N., Willer, J.R., Fievet, L., Bhuiyan, Z.A., Kleinhenz, A.L., Jadeau, J., Fulbright, J., Rivolta, C., Renella, R., Katsanis, N., Beckmann, J.S., Nicchitta, C.V., Da Costa, L., Davis, E.E., Gleizes, P.E. (2024) An atypical form of 60S ribosomal subunit in Diamond-Blackfan anemia linked to RPL17 variants. JCI insight. 9(17):
- Zhang, Y., Liu, Y., Qin, W., Zheng, S., Xiao, J., Xia, X., Yuan, X., Zeng, J., Shi, Y., Zhang, Y., Ma, H., Varshney, G.K., Fei, J.F., Liu, Y. (2024) Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish. Nature communications. 15:95269526
- Li, Y.F., Cheng, T., Zhang, Y.J., Fu, X.X., Mo, J., Zhao, G.Q., Xue, M.G., Zhuo, D.H., Xing, Y.Y., Huang, Y., Sun, X.Z., Wang, D., Liu, X., Dong, Y., Zhu, X.S., He, F., Ma, J., Chen, D., Jin, X., Xu, P.F. (2022) Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biology. 20:e3001856
- Liang, F., Zhang, Y., Li, L., Yang, Y., Fei, J.F., Liu, Y., Qin, W. (2022) SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish. Nature communications. 13:3421
- Liu, Y., Liang, F., Dong, Z., Li, S., Ye, J., Qin, W. (2021) Genome Editing in Zebrafish by ScCas9 Recognizing NNG PAM. Cells. 10(8):
- Lefkopoulos, S., Polyzou, A., Derecka, M., Bergo, V., Clapes, T., Cauchy, P., Jerez-Longres, C., Onishi-Seebacher, M., Yin, N., Martagon-Calderón, N.A., Potts, K.S., Klaeylé, L., Liu, F., Bowman, T.V., Jenuwein, T., Mione, M.C., Trompouki, E. (2020) Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 53:934-951.e9
- Wang, S., Ji, D., Yang, Q., Li, M., Ma, Z., Zhang, S., Li, H. (2018) NEFLb impairs early nervous system development via regulation of neuron apoptosis in zebrafish. Journal of Cellular Physiology. 234(7):11208-11218
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Xiao, B., Cui, L.Q., Ding, C., Wang, H. (2017) Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Zebrafish. 14(3):209-215
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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