Gene
xpc
- ID
- ZDB-GENE-030131-8461
- Name
- xeroderma pigmentosum, complementation group C
- Symbol
- xpc Nomenclature History
- Previous Names
-
- wu:fb12d05
- wu:fb12d09
- zgc:113032
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in mismatch repair and nucleotide-excision repair. Predicted to act upstream of or within DNA damage response. Predicted to be located in nucleus. Predicted to be part of XPC complex and nucleotide-excision repair factor 2 complex. Predicted to be active in cytoplasm. Is expressed in liver. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113032 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kh6 | Allele with one deletion | Exon 2 | Frameshift | CRISPR | |
| kh7 | Allele with one delins | Exon 2 | Frameshift | CRISPR | |
| kh8 | Allele with one delins | Exon 2 | Inframe Deletion | CRISPR | |
| la016323Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| xeroderma pigmentosum group C | Alliance | Xeroderma pigmentosum, group C | 278720 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair protein Rad4 | DNA repair protein Rad4-like | Papain-like cysteine peptidase superfamily | Rad4 beta-hairpin domain 1 | Rad4 beta-hairpin domain 2 | Rad4 beta-hairpin domain 3 | Rad4, beta-hairpin domain 3 superfamily | Rad4/PNGase transglutaminase-like fold | Transglutaminase-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PQU6 | InterPro | 844 | |||||||||
| UniProtKB:Q1LVE4 | InterPro | 879 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-72L14 | ZFIN Curated Data | |
| Encodes | EST | fb12d05 | ||
| Encodes | EST | fb12d09 | ||
| Encodes | EST | fd11d05 | ||
| Encodes | cDNA | MGC:113032 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198117 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045210 (1) | 3062 nt | ||
| Genomic | GenBank:BX784025 (1) | 257681 nt | ||
| Polypeptide | UniProtKB:Q1LVE4 (1) | 879 aa |
- Wilson, P.W., Cho, C., Allsing, N., Khanum, S., Bose, P., Grubschmidt, A., Sant, K.E. (2022) Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos. Birth defects research. 115(4):458-473
- Falfushynska, H., Horyn, O., Osypenko, I., Rzymski, P., Wejnerowski, Ł., Dziuba, M.K., Sokolova, I.M. (2021) Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. Water research. 194:116923
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Zhao, H., Li, H., Du, J., Di Mauro, G., Lungu-Mitea, S., Geyer, N., Vallone, D., Bertolucci, C., Foulkes, N.S. (2021) Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair. PLoS Genetics. 17:e1009356
- Viganò, L., Casatta, N., Farkas, A., Mascolo, G., Roscioli, C., Stefani, F., Vitelli, M., Olivo, F., Clerici, L., Robles, P., Dellavedova, P. (2020) Embryo/larval toxicity and transcriptional effects in zebrafish (Danio rerio) exposed to endocrine active riverbed sediments. Environmental science and pollution research international. 27(10):10729-10747
- Bereketoglu, C., Pradhan, A. (2019) Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish. The Science of the total environment. 671:129-139
- Honjo, Y., Ichinohe, T. (2019) Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Cell biology international. 43(5):516-527
- Kim, Y., Jeong, J., Chatterjee, N., Yim, U.H., Kwon, J.H., Park, M.S., Choi, J. (2019) Activation of the nucleotide excision repair pathway by crude oil exposure: A translational study from model organisms to the Hebei Spirit Oil Spill Cohort. Environmental pollution (Barking, Essex : 1987). 254:112997
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Bautista, F.E.A., Junior, A.S.V., Corcini, C.D., Acosta, I.B., Caldas, S.S., Primel, E.G., Zanette, J. (2018) The herbicide atrazine affects sperm quality and the expression of antioxidant and spermatogenesis genes in zebrafish testes. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 206-207:17-22
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