Gene
glulb
- ID
- ZDB-GENE-030131-8417
- Name
- glutamate-ammonia ligase (glutamine synthase) b
- Symbol
- glulb Nomenclature History
- Previous Names
-
- fb11d08
- gso2 (1)
- hm:zehn1949
- im:7153900
- wu:fb11d08
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable glutamine synthetase activity. Acts upstream of or within inner ear receptor cell development and neuromast hair cell development. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; hatching gland; integument; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Zhao et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital glutamine deficiency | Alliance | Glutamine deficiency, congenital | 610015 |
| developmental and epileptic encephalopathy 116 | Alliance | Developmental and epileptic encephalopathy 116 | 620806 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR027302 | Glutamine synthetase, N-terminal conserved site |
| Conserved_site | IPR027303 | Glutamine synthetase, glycine-rich site |
| Domain | IPR008146 | Glutamine synthetase, catalytic domain |
| Domain | IPR008147 | Glutamine synthetase, N-terminal domain |
| Family | IPR050292 | Glutamine Synthetase |
| Homologous_superfamily | IPR014746 | Glutamine synthetase/guanido kinase, catalytic domain |
| Homologous_superfamily | IPR036651 | Glutamine synthetase, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutamine Synthetase | Glutamine synthetase, catalytic domain | Glutamine synthetase, glycine-rich site | Glutamine synthetase/guanido kinase, catalytic domain | Glutamine synthetase, N-terminal conserved site | Glutamine synthetase, N-terminal domain | Glutamine synthetase, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVF2 | InterPro | 372 |
Interactions and Pathways
No data available
Plasmids
No data available