Gene
aldoaa
- ID
- ZDB-GENE-030131-8369
- Name
- aldolase a, fructose-bisphosphate, a
- Symbol
- aldoaa Nomenclature History
- Previous Names
-
- aldoa
- cb79 (1)
- sb:cb79
- wu:fa28b10
- wu:fb10b11
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable fructose-bisphosphate aldolase activity. Acts upstream of or within several processes, including nervous system development; somitogenesis; and thigmotaxis. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; nervous system; and paraxial mesoderm. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb79 (10 images)
- IMAGE:6904348 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Blaker-Lee et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024188Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Glycogen storage disease XII | 611881 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aldolase-type TIM barrel | Fructose-bisphosphate aldolase, class-I | Fructose-bisphosphate aldolase class-I active site |
|---|---|---|---|---|---|
| UniProtKB:Q803Q7 | InterPro | 364 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldoaa-201
(1)
|
Ensembl | 1,609 nt | ||
| mRNA |
aldoaa-203
(1)
|
Ensembl | 1,180 nt | ||
| ncRNA |
aldoaa-003
(1)
|
Ensembl | 715 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198P11 | ZFIN Curated Data | |
| Encodes | EST | cb79 | ZFIN Curated Data | |
| Encodes | EST | fa28b10 | Merritt et al., 2002 | |
| Encodes | EST | fb10b11 | ZFIN Curated Data | |
| Encodes | EST | fb16a06 | Rauch et al., 2003 | |
| Encodes | EST | IMAGE:6904348 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55367 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77198 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191367 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194377 (1) | 1614 nt | ||
| Genomic | GenBank:BX537342 (1) | 195436 nt | ||
| Polypeptide | UniProtKB:Q803Q7 (1) | 364 aa |
- Amanda, S., Tan, T.K., Ong, J.Z.L., Theardy, M.S., Wong, R.W.J., Huang, X.Z., Ali, M.Z., Li, Y., Gong, Z., Inagaki, H., Foo, E.Y., Pang, B., Tan, S.Y., Iida, S., Sanda, T. (2022) IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Nature communications. 13:2420
- Brandão, A.S., Borbinha, J., Pereira, T., Brito, P.H., Lourenço, R., Bensimon-Brito, A., Jacinto, A. (2022) A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLIFE. 11
- Charlie-Silva, I., Feitosa, N.M., Pontes, L.G., Fernandes, B.H., Nóbrega, R.H., Gomes, J.M.M., Prata, M.N.L., Ferraris, F.K., Melo, D.C., Conde, G., Rodrigues, L.F., Aracati, M.F., Corrêa-Junior, J.D., Manrique, W.G., Superio, J., Garcez, A.S., Conceição, K., Yoshimura, T.M., Núñez, S.C., Eto, S.F., Fernandes, D.C., Freitas, A.Z., Ribeiro, M.S., Nedoluzhko, A., Lopes-Ferreira, M., Borra, R.C., Barcellos, L.J.G., Perez, A.C., Malafaia, G., Cunha, T.M., Belo, M.A.A., Galindo-Villegas, J. (2022) Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts. Frontiers in immunology. 13:1019201
- Xu, Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., Li, M. (2022) Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Frontiers in endocrinology. 13:864631
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Healy, T.M., Schulte, P.M. (2019) Patterns of alternative splicing in response to cold acclimation in fish. The Journal of experimental biology. 222(Pt 5):
- Honkoop, H., de Bakker, D.E., Aharonov, A., Kruse, F., Shakked, A., Nguyen, P.D., de Heus, C., Garric, L., Muraro, M.J., Shoffner, A., Tessadori, F., Peterson, J.C., Noort, W., Bertozzi, A., Weidinger, G., Posthuma, G., Grun, D., van der Laarse, W.J., Klumperman, J., Jaspers, R.T., Poss, K.D., van Oudenaarden, A., Tzahor, E., Bakkers, J. (2019) Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLIFE. 8:
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
- Espina, J., Marchant, C., De Ferrari, G.V., Reyes, A.E. (2018) Pdgf1aa regulates zebrafish neural crest cells migration through Hif-1 in an oxygen-independent manner. Mechanisms of Development. 154:203-207
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