Gene
gna13b
- ID
- ZDB-GENE-030131-8277
- Name
- guanine nucleotide binding protein (G protein), alpha 13b
- Symbol
- gna13b Nomenclature History
- Previous Names
-
- fj64c01
- Galpha 13b (1)
- wu:fj64c01
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Acts upstream of or within several processes, including circulatory system development; gastrulation; and glial cell development. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in brush border membrane and cytoplasm. Is expressed in gill; head; intermediate cell mass of mesoderm; nervous system; and trunk. Orthologous to human GNA13 (G protein subunit alpha 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Ye et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gna13b | Okasato et al., 2021 | |
| MO1-gna13b | N/A | (12) |
| MO2-gna13b | N/A | Ye et al., 2011 |
| MO3-gna13b | N/A | Ye et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000469 | G-protein alpha subunit, group 12/13 |
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | G-protein alpha subunit, group 12/13 | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:A4FVJ5 | InterPro | 377 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gna13b-201
(1)
|
Ensembl | 1,574 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-117C2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-227L23 | ZFIN Curated Data | |
| Encodes | EST | fj64c01 | ||
| Encodes | cDNA | MGC:162498 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013263 (1) | 1604 nt | ||
| Genomic | GenBank:CU855789 (1) | 151705 nt | ||
| Polypeptide | UniProtKB:A4FVJ5 (1) | 377 aa |
- Hu, B., Pinzour, J., Patel, A., Rooney, F., Zerwic, A., Gao, Y., Nguyen, N.T., Xie, H., Ye, D., Lin, F. (2024) Gα13 controls pharyngeal endoderm convergence by regulating E-cadherin expression and RhoA activation. Development (Cambridge, England). 151(19):
- Mahabaleshwar, H., Asharani, P.V., Loo, T.Y., Koh, S.Y., Pitman, M.R., Kwok, S., Ma, J., Hu, B., Lin, F., Li Lok, X., Pitson, S.M., Saunders, T.E., Carney, T.J. (2022) Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO reports. 23(8):e54464
- Lei, D., Zhang, X., Rouf, M.A., Mahendra, Y., Wen, L., Li, Y., Zhang, X., Li, L., Wang, L., Zhang, T., Wang, G., Wang, Y. (2021) Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish. iScience. 24:103386
- Okasato, R., Kano, K., Kise, R., Inoue, A., Fukuhara, S., Aoki, J. (2021) An ATX-LPA6-Gα13-ROCK axis shapes and maintains caudal vein plexus in zebrafish. iScience. 24:103254
- Liu, D.J., Zhang, F., Chen, Y., Jin, Y., Zhang, Y.L., Chen, S.B., Xie, Y.Y., Huang, Q.H., Zhao, W.L., Wang, L., Xu, P.F., Chen, Z., Chen, S.J., Li, B., Zhang, A., Sun, X.J. (2020) setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell discovery. 6:72
- Ackerman, S.D., Luo, R., Poitelon, Y., Mogha, A., Harty, B.L., D'Rozario, M., Sanchez, N.E., Lakkaraju, A.K.K., Gamble, P., Li, J., Qu, J., MacEwan, M.R., Ray, W.Z., Aguzzi, A., Feltri, M.L., Piao, X., Monk, K.R. (2018) GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. The Journal of experimental medicine. 215(3):941-961
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813
- Xie, H., Ye, D., Sepich, D., Lin, F. (2016) S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence. Developmental Biology. 414:228-43
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