Gene
vamp2
- ID
- ZDB-GENE-030131-8225
- Name
- vesicle-associated membrane protein 2
- Symbol
- vamp2 Nomenclature History
- Previous Names
-
- wu:fj61c06
- zgc:73302
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Predicted to be involved in SNARE complex assembly. Predicted to act upstream of or within vesicle-mediated transport. Located in cleavage furrow and vesicle. Is expressed in blastomere; head; nervous system; and pancreatic system. Orthologous to human VAMP2 (vesicle associated membrane protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73302 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017462Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa38797 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ue702Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vamp2 | Zhang et al., 2023 | |
| CRISPR2-vamp2 | Zhang et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements | 618760 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Synaptobrevin-like | Synaptobrevin/Vesicle-associated membrane protein | v-SNARE, coiled-coil homology domain |
|---|---|---|---|---|---|
| UniProtKB:Q7SZZ5 | InterPro | 110 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(5xUAS:vamp2-Venus) |
|
| 1 | Asakawa et al., 2018 | |
| Tg(elavl3:spHGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-237L4 | ||
| Encodes | EST | fj61c06 | ||
| Encodes | cDNA | MGC:73302 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200005 (1) | 894 nt | ||
| Genomic | GenBank:AL807389 (1) | 143672 nt | ||
| Polypeptide | UniProtKB:Q7SZZ5 (1) | 110 aa |
- Zhang, Y., Marshall-Phelps, K., Almeida, R.G. (2023) Fast, precise and cloning-free knock-in of reporter sequences in vivo with high efficiency. Development (Cambridge, England). 150(12):
- Hajiabadi, H., Mamontova, I., Prizak, R., Pancholi, A., Koziolek, A., Hilbert, L. (2022) Deep-learning microscopy image reconstruction with quality control reveals second-scale rearrangements in RNA polymerase II clusters. PNAS nexus. 1:pgac065pgac065
- Pan, W., Godoy, R.S., Cook, D.P., Scott, A.L., Nurse, C.A., Jonz, M.G. (2022) Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Scientific Reports. 12:10144
- Hughes, A.N., Appel, B. (2019) Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. Nature communications. 10:4125
- Marass, M., Beisaw, A., Gerri, C., Luzzani, F., Fukuda, N., Günther, S., Kuenne, C., Reischauer, S., Stainier, D.Y.R. (2019) Genome-wide strategies reveal target genes of Npas4l associated with vascular development in zebrafish. Development (Cambridge, England). 146(11):
- Asakawa, K., Kawakami, K. (2018) Protocadherin-Mediated Cell Repulsion Controls the Central Topography and Efferent Projections of the Abducens Nucleus. Cell Reports. 24:1562-1572
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Prats, E., Gómez-Canela, C., Ben-Lulu, S., Ziv, T., Padrós, F., Tornero, D., Garcia-Reyero, N., Tauler, R., Admon, A., Raldúa, D. (2017) Modelling acrylamide acute neurotoxicity in zebrafish larvae. Scientific Reports. 7:13952
- Fontenas, L., De Santis, F., Di Donato, V., Degerny, C., Chambraud, B., Del Bene, F., Tawk, M. (2016) Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish. PLoS Genetics. 12:e1006459
- Wen, H., Hubbard, J.M., Wang, W.C., Brehm, P. (2016) Fatigue in Rapsyn-Deficient Zebrafish Reflects Defective Transmitter Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:10870-10882
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