Gene
supt6h
- ID
- ZDB-GENE-030131-7949
- Name
- SPT6 homolog, histone chaperone and transcription elongation factor
- Symbol
- supt6h Nomenclature History
- Previous Names
-
- pan
- Spt6 (1)
- pandora
- wu:fj42h11
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable histone binding activity and nucleosome binding activity. Involved in transcription elongation-coupled chromatin remodeling. Acts upstream of or within embryonic heart tube development; otic vesicle development; and somitogenesis. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Keegan et al., 2002
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1621Tg | Transgenic insertion | Intron 25 | Unknown | DNA | |
| hi2505bTg | Transgenic insertion | 5' UTR | Unknown | DNA | |
| la014035Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021916Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m313 | Allele with one point mutation | Unknown | Splice Site, Intron Gain, Frameshift, Premature Stop | ENU | |
| sa16076 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16191 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23947 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37322 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37323 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-supt6h | N/A | Kok et al., 2007 |
| MO2-supt6h | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-turn-helix DNA-binding domain of Spt6 | HHH domain 9 | Nucleic acid-binding, OB-fold | Ribonuclease H-like superfamily | RuvA domain 2-like | S1 domain | SH2 domain | SH2 domain superfamily | Spt6 acidic, N-terminal domain | Spt6, Death-like domain | Spt6, SH2 domain | Spt6, SH2 domain, C terminus | Spt6, SH2 domain, N terminus | Tex-like, central region | Tex-like domain superfamily | Tex-like protein, HTH domain superfamily | Transcription elongation factor Spt6 | Transcription elongation factor Spt6, helix-hairpin-helix motif | Transcription elongation factor Spt6, YqgF domain | YqgF/RNase H-like domain | YqgF/RNase H-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AWY8 | InterPro | 1728 | |||||||||||||||||||||
| UniProtKB:Q8UVK2 | InterPro | 1726 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
supt6h-201
(1)
|
Ensembl | 6,394 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-220H13 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-6A12 | ZFIN Curated Data | |
| Encodes | EST | fj42h11 | ||
| Encodes | cDNA | MGC:63881 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_145118 (1) | 6340 nt | ||
| Genomic | GenBank:BX294122 (2) | 162708 nt | ||
| Polypeptide | UniProtKB:A0A8M3AWY8 (1) | 1728 aa |
- Conant, G.C. (2020) The lasting after-effects of an ancient polyploidy on the genomes of teleosts. PLoS One. 15:e0231356
- Duan, J., Hu, H., Zhang, Y., Feng, L., Shi, Y., Miller, M.R., Sun, Z. (2017) Multi-organ toxicity induced by fine particulate matter PM2.5 in zebrafish (Danio rerio) model.. Chemosphere. 180:24-32
- Gao, S., Liu, S., Yao, J., Li, N., Yuan, Z., Zhou, T., Li, Q., Liu, Z. (2017) Genomic organization and evolution of olfactory receptors and trace amine-associated receptors in channel catfish, Ictalurus punctatus. Biochimica et biophysica acta. 1861(3):644-651
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, A.H., Zare, H., Mousavi, K., Wang, C., Moravec, C.E., Sirotkin, H.I., Ge, K., Gutierrez-Cruz, G., and Sartorelli, V. (2013) The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. The EMBO journal. 32(8):1075-86
- Ahn, D., You, K.H., and Kim, C.H. (2012) Evolution of the Tbx6/16 Subfamily Genes in Vertebrates: Insights from Zebrafish. Mol. Biol. Evol.. 29(12):3959-3983
- Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559
- Serluca, F.C. (2008) Development of the proepicardial organ in the zebrafish. Developmental Biology. 315(1):18-27
- Kok, F.O., Oster, E., Mentzer, L., Hsieh, J.C., Henry, C.A., and Sirotkin, H.I. (2007) The role of the SPT6 chromatin remodeling factor in zebrafish embryogenesis. Developmental Biology. 307(2):214-226
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