Gene
kdm1a
- ID
- ZDB-GENE-030131-7828
- Name
- lysine (K)-specific demethylase 1a
- Symbol
- kdm1a Nomenclature History
- Previous Names
-
- kdm1
- aof2
- lsd1 (1)
- wu:fb82e06
- wu:fc51a02
- wu:fj36a05
- wu:fj66b06
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables histone deacetylase activity. Acts upstream of or within nervous system development; regulation of hemopoiesis; and regulation of retinoic acid biosynthetic process. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Is expressed in brain; head; intestine; and spinal cord. Used to study myelodysplastic syndrome. Orthologous to human KDM1A (lysine demethylase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
aik5 | Allele with one deletion | Exon 1 | Missense, Premature Stop | CRISPR | |
it627 | Allele with one point mutation | Exon 17 | Premature Stop | ENU | |
sa23095 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa28869 | Allele with one point mutation | Unknown | Unknown | ENU | |
sa36433 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa42949 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
myelodysplastic syndrome | AB + MO4-kdm1a | standard conditions | Wu et al., 2021 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Amine oxidase | FAD/NAD(P)-binding domain superfamily | Flavin monoamine oxidase and related enzymes | Homedomain-like superfamily | Lysine-specific histone demethylase | SWIRM domain | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:F6NIA2 | InterPro | 833 | |||||||
UniProtKB:A0A0P0UQI8 | InterPro | 830 | |||||||
UniProtKB:A0JMQ3 | InterPro | 848 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001242995 (1) | 3352 nt | ||
Genomic | GenBank:AL844186 (1) | 221158 nt | ||
Polypeptide | UniProtKB:A0JMQ3 (1) | 848 aa |
- Faillace, M.P., Ortiz, J., Rocco, L., Bernabeu, R. (2024) Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish. Molecular neurobiology. 61(9):6245-6263
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Tamaoki, J., Maeda, H., Kobayashi, I., Takeuchi, M., Ohashi, K., Gore, A., Bonkhofer, F., Patient, R., Weinstein, B.M., Kobayashi, M. (2023) LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Developmental Biology. 501:92-103
- Casey, M.J., Call, A.M., Thorpe, A.V., Jette, C.A., Engel, M.E., Stewart, R.A. (2022) The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis. iScience. 26:105737105737
- Wu, M., Chen, Q., Li, J., Xu, Y., Lian, J., Liu, Y., Meng, P., Zhang, Y. (2022) Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish. Frontiers in cell and developmental biology. 9:786426
- DeLaurier, A., Howe, D.G., Ruzicka, L., Carte, A.N., Mishoe Hernandez, L., Wiggins, K.J., Gallati, M.M., Vanpelt, K., Loyo Rosado, F., Pugh, K.G., Shabdue, C.J., Jihad, K., Thyme, S.B., Talbot, J.C. (2021) ZebraShare: a new venue for rapid dissemination of zebrafish mutant data. PeerJ. 9:e11007
- Matrone, G., Jung, S.Y., Choi, J.M., Jain, A., Leung, H.E., Rajapakshe, K., Coarfa, C., Rodor, J., Denvir, M.A., Baker, A.H., Cooke, J.P. (2021) Nuclear S-nitrosylation impacts tissue regeneration in zebrafish. Nature communications. 12:6282
- Wu, M., Xu, Y., Li, J., Lian, J., Chen, Q., Meng, P., Lu, T., Xie, H., Zhang, W., Xu, J., Zhang, Y. (2021) Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpα in zebrafish neutrophil development. Development (Cambridge, England). 148(17)
- Tamaoki, J., Takeuchi, M., Abe, R., Kaneko, H., Wada, T., Hino, S., Nakao, M., Furukawa, Y., Kobayashi, M. (2020) Splicing- and demethylase-independent functions of LSD1 in zebrafish primitive hematopoiesis. Scientific Reports. 10:8521
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
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