Gene
prmt8b
- ID
- ZDB-GENE-030131-7791
- Name
- protein arginine methyltransferase 8b
- Symbol
- prmt8b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables arginine N-methyltransferase activity. Acts upstream of or within dendrite morphogenesis and midbrain-hindbrain boundary development. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain; eye; and somite. Orthologous to human PRMT8 (protein arginine methyltransferase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-prmt8b | N/A | (2) |
| MO2-prmt8b | N/A | Lin et al., 2013 |
| MO3-prmt8b | N/A | Huang et al., 2013 |
| MO4-prmt8b | N/A | Kim et al., 2015 |
| TALEN1-prmt8b | (3) |
1 - 5 of 5
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Methyltransferase domain 25 | Protein arginine N-methyltransferase | Protein arginine N-methyltransferase domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q6G4 | InterPro | 420 | ||||
| UniProtKB:A0A8M9Q5Y0 | InterPro | 418 | ||||
| UniProtKB:Q5RGQ2 | InterPro | 419 | ||||
| UniProtKB:A0A2R8QJ87 | InterPro | 334 |
1 - 4 of 4
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prmt8b-201
(1)
|
Ensembl | 3,776 nt | ||
| mRNA |
prmt8b-202
(1)
|
Ensembl | 1,005 nt | ||
| mRNA |
prmt8b-203
(1)
|
Ensembl | 6,147 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-21H14 | ZFIN Curated Data | |
| Encodes | EST | fj34f03 | ||
| Encodes | cDNA | MGC:194353 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194375 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045042 (1) | 1005 nt | ||
| Genomic | GenBank:BX784029 (1) | 219903 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q6G4 (1) | 420 aa |
- Haug, M.F., Gesemann, M., Lazovic, V., Neuhauss, S.C. (2015) Eumetazoan Cryptochrome Phylogeny and Evolution. Genome biology and evolution. 7(2):601-19
- Kim, J.D., Park, K.E., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M., Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., Fukamizu, A. (2015) PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination. Science advances. 1:e1500615
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Lin, Y.L., Tsai, Y.J., Liu, Y.F., Cheng, Y.C., Hung, C.M., Lee, Y.J., Pan, H., and Li, C. (2013) The Critical Role of Protein Arginine Methyltransferase prmt8 in Zebrafish Embryonic and Neural Development Is Non-Redundant with Its Paralogue prmt1. PLoS One. 8(3):e55221
- Wang, H. (2009) Comparative genomic analysis of teleost fish bmal genes. Genetica. 136(1):149-161
- Dong, C.W., Zhang, Y.B., Lu, A.J., Zhu, R., Zhang, F.T., Zhang, Q.Y., and Gui, J.F. (2007) Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Fish & shellfish immunology. 22(4):380-393
- Hung, C.M., and Li, C. (2004) Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians. Gene. 340(2):179-187
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 8 of 8
Show