Gene
gas6
- ID
- ZDB-GENE-030131-7773
- Name
- growth arrest-specific 6
- Symbol
- gas6 Nomenclature History
- Previous Names
-
- fj34a12
- wu:fj34a12
- zgc:63860
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in extracellular region. Is expressed in heart; nervous system; and neural tube. Orthologous to human GAS6 (growth arrest specific 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63860 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9012 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19391 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32572 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| stl228 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| um296 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| um297 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| um298 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| um299 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| zko14a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko14b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gas6 | (2) | |
| CRISPR2-gas6 | Giera et al., 2018 | |
| CRISPR3-gas6 | Ghosh et al., 2018 | |
| CRISPR4-gas6 | (2) | |
| CRISPR5-gas6 | Lin et al., 2025 | |
| CRISPR6-gas6 | Lin et al., 2025 | |
| MO1-gas6 | N/A | Kim et al., 2014 |
| MO2-gas6 | N/A | Kim et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor-like, Gla domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent | Laminin G domain | NOTCH1 EGF-like calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T3H4 | InterPro | 648 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-129C2 | ZFIN Curated Data | |
| Encodes | EST | fj34a12 | ||
| Encodes | cDNA | MGC:63860 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199978 (1) | 2472 nt | ||
| Genomic | GenBank:CU179747 (2) | 162432 nt | ||
| Polypeptide | UniProtKB:Q7T3H4 (1) | 648 aa |
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Giera, S., Luo, R., Ying, Y., Ackerman, S.D., Jeong, S.J., Stoveken, H.M., Folts, C.J., Welsh, C.A., Tall, G.G., Stevens, B., Monk, K.R., Piao, X. (2018) Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. eLIFE. 7
- Yu, S., Li, C., Biswas, L., Hu, X., Liu, F., Reilly, J., Liu, X., Liu, Y., Huang, Y., Lu, Z., Han, S., Wang, L., Liu, J.Y., Jiang, T., Shu, X., Wong, F., Tang, Z., Liu, M. (2017) CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Human molecular genetics. 26(12):2335-2345
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kim, Y.S., Jung, S.H., Jung, D.H., Choi, S.J., Lee, Y.R., and Kim, J.S. (2014) Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling. PLoS One. 9(1):e83901
- Choe, S.K., Zhang, X., Hirsch, N., Straubhaar, J., and Sagerström, C.G. (2011) A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Developmental Biology. 358(2):356-67
- Chen, J., Carney, S.A., Peterson, R.E., and Heideman, W. (2008) Comparative Genomics Identifies Genes Mediating Cardiotoxicity in the Embryonic Zebrafish Heart. Physiological Genomics. 33(2):148-158
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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