Gene
zfhx3b
- ID
- ZDB-GENE-030131-7577
- Name
- zinc finger homeobox 3b
- Symbol
- zfhx3b Nomenclature History
- Previous Names
-
- zfhx3
- fd23d06
- fj32b02
- im:7148790
- wu:fd23d06
- wu:fj32b02
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in nervous system and pharyngeal arch. Human ortholog(s) of this gene implicated in familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); prostate cancer; and spinocerebellar ataxia type 4. Orthologous to human ZFHX3 (zinc finger homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154126 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13073 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13265 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18256 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21139 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21140 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31615 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa34236 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38655 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa41077 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-zfhx3b | Varshney et al., 2015 | |
| CRISPR2-zfhx3b | Varshney et al., 2015 | |
| MO1-zfhx3b | N/A | Fuller et al., 2018 |
| MO2-zfhx3b | N/A | Fuller et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial atrial fibrillation | Alliance | {Atrial fibrillation 8, susceptibility to} | 613055 |
| prostate cancer | Alliance | Prostate cancer, somatic | 176807 |
| spinocerebellar ataxia type 4 | Alliance | Spinocerebellar ataxia 4 | 600223 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Matrin/U1-C-like, C2H2-type zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger homeobox transcription regulators |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PQC4 | InterPro | 2621 | |||||||
| UniProtKB:A0A8M9QI68 | InterPro | 3838 | |||||||
| UniProtKB:A0AB32TRX9 | InterPro | 3802 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-165L19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-38P8 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-475H23 | ZFIN Curated Data | |
| Encodes | EST | fd23d06 | ||
| Encodes | EST | fj32b02 | ||
| Encodes | EST | IMAGE:7148790 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7154126 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001365188 (1) | 16701 nt | ||
| Genomic | GenBank:BX511086 (2) | 228170 nt | ||
| Polypeptide | UniProtKB:A0A8M9QI68 (1) | 3838 aa |
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Liu, S., Xu, L., Kashima, M., Narumi, R., Takahata, Y., Nakamura, E., Shibuya, H., Tamura, M., Shida, Y., Inubushi, T., Nukada, Y., Miyazawa, M., Hata, K., Nishimura, R., Yamashiro, T., Tasaki, J., Kurosaka, H. (2024) Expression analysis of genes including Zfhx4 in mice and zebrafish reveals a temporospatial conserved molecular basis underlying craniofacial development. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Fuller, T.D., Westfall, T.A., Das, T., Dawson, D.V., Slusarski, D.C. (2018) High-throughput behavioral assay to investigate seizure sensitivity in zebrafish implicates ZFHX3 in epilepsy. Journal of neurogenetics. 32(2):92-105
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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