Gene
rgs5a
- ID
- ZDB-GENE-030131-7570
- Name
- regulator of G protein signaling 5a
- Symbol
- rgs5a Nomenclature History
- Previous Names
-
- rgs5
- fj30h05
- wu:fj30h05
- zgc:64006 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to be located in membrane. Is expressed in bulbus arteriosus; cranial blood vessel; eye; and trunk vasculature. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and essential hypertension. Orthologous to human RGS5 (regulator of G protein signaling 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | [Blood pressure regulation QTL] | 145500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | RGS domain | RGS domain superfamily | RGS, subdomain 1/3 | RGS, subdomain 2 |
|---|---|---|---|---|---|---|
| UniProtKB:Q7T2D3 | InterPro | 182 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-232F6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-39O12 | ZFIN Curated Data | |
| Encodes | EST | fj30h05 | ||
| Encodes | cDNA | MGC:64006 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174043 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198190 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198196 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199962 (1) | 2765 nt | ||
| Genomic | RefSeq:NW_018394656 (1) | 349660 nt | ||
| Polypeptide | UniProtKB:Q7T2D3 (1) | 182 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Kapuria, S., Bai, H., Fierros, J., Huang, Y., Ma, F., Yoshida, T., Aguayo, A., Kok, F., Wiens, K.M., Yip, J.K., McCain, M.L., Pellegrini, M., Nagashima, M., Hitchcock, P.F., Mochizuki, N., Lawson, N.D., Harrison, M.M.R., Lien, C.L. (2022) Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration. Development (Cambridge, England). 149(4):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Venero Galanternik, M., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratman, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., Weinstein, B.M. (2017) A novel perivascular cell population in the zebrafish brain. eLIFE. 6
- Singh, A.R., Sivadas, A., Sabharwal, A., Vellarikal, S.K., Jayarajan, R., Verma, A., Kapoor, S., Joshi, A., Scaria, V., Sivasubbu, S. (2016) Chamber Specific Gene Expression Landscape of the Zebrafish Heart. PLoS One. 11:e0147823
- Wang, Y., Pan, L., Moens, C.B., and Appel, B. (2014) Notch3 establishes brain vascular integrity by regulating pericyte number. Development (Cambridge, England). 141(2):307-317
- Cheng, Y.C., Scotting, P.J., Hsu, L.S., Lin, S.J., Shih, H.Y., Hsieh, F.Y., Wu, H.L., Tsao, C.L., and Shen, C.J. (2013) Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling. Cellular and molecular life sciences : CMLS. 70(5):935-950
- Johnston, I.A., Lee, H.T., Macqueen, D.J., Paranthaman, K., Kawashima, C., Anwar, A., Kinghorn, J.R., and Dalmay, T. (2009) Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. The Journal of experimental biology. 212(Pt 12):1781-1793
- Vihtelic, T.S., Fadool, J.M., Gao, J., Thornton, K.A., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Molecular Vision. 11:1083-1100
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