Gene
spry2
- ID
- ZDB-GENE-030131-7038
- Name
- sprouty RTK signaling antagonist 2
- Symbol
- spry2 Nomenclature History
- Previous Names
-
- wu:fk66h11
- wu:fk93e11
- zgc:110440
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Acts upstream of or within blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and sensory system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Labalette et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la013667Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa39533 | Allele with one point mutation | Unknown | Splice Site | ENU | |
zko92a | Allele with one delins | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-spry2 | (2) | |
CRISPR2-spry2 | (2) | |
CRISPR3-spry2 | (2) | |
MO1-spry2 | N/A | (3) |
MO2-spry2 | N/A | Banjo et al., 2013 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
{?IgA nephropathy, susceptibility to, 3} | 616818 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Sprouty | Sprouty domain-containing protein |
---|---|---|---|---|
UniProtKB:F1QU39 | InterPro | 301 | ||
UniProtKB:Q4VBS7 | InterPro | 301 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(UAS:spry2-UTRnanos3) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-32C16 | ZFIN Curated Data | |
Encodes | EST | fk66h11 | ||
Encodes | EST | fk93e11 | ||
Encodes | cDNA | MGC:110440 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001003842 (1) | 1801 nt | ||
Genomic | GenBank:CU694659 (2) | 170210 nt | ||
Polypeptide | UniProtKB:F1QU39 (1) | 301 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Harish, R.K., Gupta, M., Zöller, D., Hartmann, H., Gheisari, A., Machate, A., Hans, S., Brand, M. (2023) Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation. Development (Cambridge, England). 150(19):
- Song, Y., Hyeon, C. (2021) Cost-precision trade-off relation determines the optimal morphogen gradient for accurate biological pattern formation. eLIFE. 10:
- Lush, M.E., Diaz, D.C., Koenecke, N., Baek, S., Boldt, H., St Peter, M.K., Gaitan-Escudero, T., Romero-Carvajal, A., Busch-Nentwich, E.M., Perera, A.G., Hall, K.E., Peak, A., Haug, J.S., Piotrowski, T. (2019) scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling. eLIFE. 8:
- Musa, G., Srivastava, S., Petzold, J., Cazorla-Vázquez, S., Engel, F.B. (2019) miR-27a/b is a posttranscriptional regulator of Gpr126 (Adgrg6). Annals of the New York Academy of Sciences. 1456(1):109-121
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J. (2018) Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development. Mechanisms of Development. 150:28-41
- Jagadeeshan, S., Sagayaraj, R.V., Paneerselvan, N., Ghouse, S.S., Malathi, R. (2017) Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model. Cell biology and toxicology. 33(1):41-56
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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