Gene
map4k4
- ID
- ZDB-GENE-030131-6722
- Name
- mitogen-activated protein kinase kinase kinase kinase 4
- Symbol
- map4k4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-map4k4 | N/A | Koppen et al., 2006 |
| MO2-map4k4 | N/A | Patterson et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001180 | Citron homology (CNH) domain |
| Family | IPR051700 | STE20 Ser/Thr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Citron homology (CNH) domain | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | STE20 Ser/Thr Protein Kinase |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QB07 | InterPro | 930 | |||||
| UniProtKB:A0A8M9QFN8 | InterPro | 1006 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map4k4-201
(1)
|
Ensembl | 3,759 nt | ||
| mRNA |
map4k4-202
(1)
|
Ensembl | 5,045 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-433A6 | ZFIN Curated Data | |
| Encodes | EST | fa03e11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021478791 (1) | 4719 nt | ||
| Genomic | GenBank:CU694490 (2) | 37993 nt | ||
| Polypeptide | UniProtKB:A0A8M9QFN8 (1) | 1006 aa |
- Patterson, V., Ullah, F., Bryant, L., Dong, L.I., Griffin, J.N., Sidhu, A., Saliganan, S., Blaile, M., Saenz, M.S., Smith, R., Ellingwood, S., Grange, D.K., Hu, X., Mireguli, M., Luo, Y., Shen, Y., Mulhern, M., Zackai, E., Ritter, A., Izumi, K., Hoefele, J., Wagner, M., Riedhammer, K.M., Seitz, B., Robin, N.H., Goodloe, D., Mignot, C., Keren, B., Cox, H., Jarvis, J., Hempel, M., Gibson, C.F., Tran Mau-Them, F., Vitobello, A., Bruel, A.L., Sorlin, A., Mehta, S., Raymond, F.L., Gilmore, K., Powell, B.C., Weck, K., Li, C., Vulto-van Silfhout, A.T., Giacomini, T., Mancardi, M.M., Accogli, A., Salpietro, V., Zara, F., Vora, N.L., Davis, E.E., Burdine, R.D., Bhoj, E. (2023) Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. Science advances. 9:eade0631
- Koppen, M., Fernandez, B.G., Carvalho, L., Jacinto, A., and Heisenberg, C.P. (2006) Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Development (Cambridge, England). 133(14):2671-2681
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