Gene

gnl3

ID
ZDB-GENE-030131-616
Name
G protein nucleolar 3
Symbol
gnl3 Nomenclature History
Previous Names
  • id:ibd2914
  • nstm (1)
  • nucleostemin
  • wu:fb38a04
  • wu:fc55d07
  • zgc:123093
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable GTP binding activity. Acts upstream of or within several processes, including exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); neural retina development; and regulation of exit from mitosis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in head; immature eye; midbrain; and somite. Orthologous to human GNL3 (G protein nucleolar 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hi299TgTransgenic insertionIntron 1UnknownDNA
hu3259Allele with one point mutationExon 5Premature Stopnot specified
sa41766Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-gnl3N/AScott et al., 2021
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Human Disease
Associated With gnl3 Human Ortholog
No data available
Associated With gnl3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006073 GTP binding domain
Domain IPR014813 Guanine nucleotide-binding protein-like 3, N-terminal domain
Domain IPR030378 Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
Family IPR050755 TRAFAC YlqF/YawG GTPases, Ribosome Maturation
Homologous_superfamily IPR023179 GTP-binding protein, orthogonal bundle domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Circularly permuted (CP)-type guanine nucleotide-binding (G) domain GTP binding domain GTP-binding protein, orthogonal bundle domain superfamily Guanine nucleotide-binding protein-like 3, N-terminal domain P-loop containing nucleoside triphosphate hydrolase TRAFAC YlqF/YawG GTPases, Ribosome Maturation
UniProtKB:Q6DRP2 InterPro 561
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gnl3-202 (1) Ensembl 2,090 nt
ncRNA gnl3-002 (1) Ensembl 773 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-80B12ZFIN Curated Data
EncodesESTfb38a04
EncodesESTfc55d07
EncodesESTibd2914
EncodescDNAMGC:123093ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanGNL33
Amino acid sequence comparison (3)
Conserved genome location (synteny) (1)
MouseGnl314
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
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