Gene
gnl3
- ID
- ZDB-GENE-030131-616
- Name
- G protein nucleolar 3
- Symbol
- gnl3 Nomenclature History
- Previous Names
-
- id:ibd2914
- nstm (1)
- nucleostemin
- wu:fb38a04
- wu:fc55d07
- zgc:123093
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity. Acts upstream of or within several processes, including exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); neural retina development; and regulation of exit from mitosis. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in head; immature eye; midbrain; and somite. Orthologous to human GNL3 (G protein nucleolar 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR006073 | GTP binding domain |
Domain | IPR014813 | Guanine nucleotide-binding protein-like 3, N-terminal domain |
Domain | IPR030378 | Circularly permuted (CP)-type guanine nucleotide-binding (G) domain |
Family | IPR050755 | TRAFAC YlqF/YawG GTPases, Ribosome Maturation |
Homologous_superfamily | IPR023179 | GTP-binding protein, orthogonal bundle domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | Circularly permuted (CP)-type guanine nucleotide-binding (G) domain | GTP binding domain | GTP-binding protein, orthogonal bundle domain superfamily | Guanine nucleotide-binding protein-like 3, N-terminal domain | P-loop containing nucleoside triphosphate hydrolase | TRAFAC YlqF/YawG GTPases, Ribosome Maturation |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6DRP2 | InterPro | 561 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-80B12 | ZFIN Curated Data | |
Encodes | EST | fb38a04 | ||
Encodes | EST | fc55d07 | ||
Encodes | EST | ibd2914 | ||
Encodes | cDNA | MGC:123093 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001002297 (1) | 2074 nt | ||
Genomic | GenBank:CR450797 (2) | 101488 nt | ||
Polypeptide | UniProtKB:Q6DRP2 (1) | 561 aa |
- Peña, O.A., Lubin, A., Rowell, J., Hoade, Y., Khokhar, N., Lemmik, H., Mahony, C., Dace, P., Umamahesan, C., Payne, E.M. (2021) Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish. Frontiers in cell and developmental biology. 9:708113
- Scott, H.A., Larson, A., Rong, S.S., Mehrotra, S., Butcher, R., Chao, K.R., Wiggs, J., Place, E.M., Pierce, E.A., Bujakowska, K.M. (2021) A Hidden Structural Variation in a Known IRD Gene: A Cautionary Tale of Two New Disease Candidate Genes. Cold Spring Harbor molecular case studies. 8(2):
- Luo, J., Zhang, X., He, S., Lou, Q., Zhai, G., Shi, C., Yin, Z., Zheng, F. (2019) Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology. 28:101355
- Chakraborty, A., Uechi, T., Nakajima, Y., Gazda, H.T., O'Donohue, M.F., Gleizes, P.E., Kenmochi, N. (2017) Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models. Biochemical and Biophysical Research Communications. 495(2):1839-1845
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Essers, P.B., Pereboom, T.C., Goos, Y.J., Paridaen, J.T., and Macinnes, A.W. (2014) A comparative study of nucleostemin family members in zebrafish reveals specific roles in ribosome biogenesis. Developmental Biology. 385(2):304-15
- Paridaen, J.T., Janson, E., Utami, K.H., Pereboom, T.C., Essers, P.B., van Rooijen, C., Zivkovic, D., and Macinnes, A.W. (2011) The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish. Developmental Biology. 355(2):286-301
- Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618
- Harden, M.V., Newton, L.A., Lloyd, R.C., Whitlock, K.E. (2006) Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Journal of neurobiology. 66(13):1452-1466
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
1 - 10 of 12
Show