Gene
ckmt1
- ID
- ZDB-GENE-030131-611
- Name
- creatine kinase, mitochondrial 1
- Symbol
- ckmt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in nervous system; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human CKMT1A (creatine kinase, mitochondrial 1A) and CKMT1B (creatine kinase, mitochondrial 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55538 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa44304 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022415 | ATP:guanido phosphotransferase active site |
| Domain | IPR022413 | ATP:guanido phosphotransferase, N-terminal |
| Domain | IPR022414 | ATP:guanido phosphotransferase, catalytic domain |
| Family | IPR000749 | ATP:guanido phosphotransferase |
| Homologous_superfamily | IPR014746 | Glutamine synthetase/guanido kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATP:guanido phosphotransferase | ATP:guanido phosphotransferase active site | ATP:guanido phosphotransferase, catalytic domain | ATP:guanido phosphotransferase, N-terminal | ATP:guanido phosphotransferase, N-terminal domain superfamily | Glutamine synthetase/guanido kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUN7 | InterPro | 417 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-147K9 | ZFIN Curated Data | |
| Contains | SNP | rs3729372 | ZFIN Curated Data | |
| Encodes | EST | fb37h03 | ||
| Encodes | EST | fb69a12 | ||
| Encodes | cDNA | MGC:55538 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192653 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198801 (1) | 1812 nt | ||
| Genomic | GenBank:CR788324 (1) | 193361 nt | ||
| Polypeptide | UniProtKB:Q7ZUN7 (1) | 417 aa |
No data available
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
- Jiao, Y., Yang, S., Min, G., Zhang, Y., Du, X., Wang, Q. (2019) Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Fish & shellfish immunology. 92:241-248
- Ma, Q., Hu, C.T., Yue, J., Luo, Y., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2019) High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish. Fish physiology and biochemistry. 46(2):665-679
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ebrahimie, E., Moussavi-Nik, S.H., Newman, M., Van Der Hoek, M., Lardelli, M. (2016) The Zebrafish Equivalent of Alzheimer's Disease-Associated PRESENILIN Isoform PS2V Regulates Inflammatory and Other Responses to Hypoxic Stress. Journal of Alzheimer's disease : JAD. 52(2):581-608
- Zhang, Y., Bonilla, S., Chong, L., and Leung, Y.F. (2013) Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas. Gene expression patterns : GEP. 13(5-6):177-82
- Hensley, M.R., Emran, F., Bonilla, S., Zhang, L., Zhong, W., Grosu, P., Dowling, J.E., and Leung, Y.F. (2011) Cellular Expression of Smarca4 (Brg1)-regulated Genes in Zebrafish Retinas. BMC Developmental Biology. 11(1):45
- Singh, S.K., Sundaram, C.S., Shanbhag, S., and Idris, M.M. (2010) Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 7(2):169-177
- Hart, D.O., Raha, T., Lawson, N.D., and Green, M.R. (2007) Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Nature. 450(7172):1082-1085
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