Gene
eno1a
- ID
- ZDB-GENE-030131-6048
- Name
- enolase 1a, (alpha)
- Symbol
- eno1a Nomenclature History
- Previous Names
-
- eno1
- wu:fi32b03
- wu:fk58e02
- zgc:73152
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. Predicted to be located in cytoplasm. Predicted to be part of phosphopyruvate hydratase complex. Is expressed in several structures, including axis; margin; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73152 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24319 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Enolase | Enolase, conserved site | Enolase, C-terminal TIM barrel domain | Enolase-like, C-terminal domain superfamily | Enolase-like, N-terminal | Enolase, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q1X2 | InterPro | 432 | ||||||
| UniProtKB:Q6IQP5 | InterPro | 432 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-28E16 | ZFIN Curated Data | |
| Encodes | EST | fi32b03 | ||
| Encodes | EST | fk58e02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73152 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86675 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212722 (1) | 1797 nt | ||
| Genomic | GenBank:CR388207 (1) | 191838 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q1X2 (1) | 432 aa |
- Prykhozhij, S.V., Ban, K., Brown, Z.L., Kobar, K., Wajnberg, G., Fuller, C., Chacko, S., Lacroix, J., Crapoulet, N., Midgen, C., Shlien, A., Malkin, D., Berman, J.N. (2024) miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage. PLoS Genetics. 20:e1011290e1011290
- Brandão, A.S., Borbinha, J., Pereira, T., Brito, P.H., Lourenço, R., Bensimon-Brito, A., Jacinto, A. (2022) A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLIFE. 11
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Kalka, M., Markiewicz, N., Ptak, M., Sone, E.D., Ożyhar, A., Dobryszycki, P., Wojtas, M. (2019) In vivo and in vitro analysis of starmaker activity in zebrafish otolith biomineralization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(6):6877-6886
- Maimouni, S., Lee, M.H., Sung, Y.M., Hall, M., Roy, A., Ouaari, C., Hwang, Y.S., Spivak, J., Glasgow, E., Swift, M., Patel, J., Cheema, A., Kumar, D., Byers, S. (2019) Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival. Oncotarget. 10:1606-1624
- Khansari, A.R., Balasch, J.C., Vallejos-Vidal, E., Teles, M., Fierro-Castro, C., Tort, L., Reyes-López, F.E. (2018) Comparative study of stress and immune-related transcript outcomes triggered by Vibrio anguillarum bacterin and air exposure stress in liver and spleen of gilthead seabream (Sparus aurata), zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss). Fish & shellfish immunology. 86:436-448
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Eastlake, K., Heywood, W.E., Tracey-White, D., Aquino, E., Bliss, E., Vasta, G.R., Mills, K., Khaw, P.T., Moosajee, M., Limb, G.A. (2017) Comparison of proteomic profiles in the zebrafish retina during experimental degeneration and regeneration. Scientific Reports. 7:44601
- Karanth, S., Zinkhan, E.K., Hill, J.T., Yost, H.J., Schlegel, A. (2016) FOXN3 Regulates Hepatic Glucose Utilization. Cell Reports. 15(12):2745-55
- Carneiro, M., Gutiérrez-Praena, D., Osório, H., Vasconcelos, V., Carvalho, A.P., Campos, A. (2015) Proteomic analysis of anatoxin-a acute toxicity in zebrafish reveals gender specific responses and additional mechanisms of cell stress. Ecotoxicology and environmental safety. 120:93-101
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