Gene
hsd11b2
- ID
- ZDB-GENE-030131-6030
- Name
- hydroxysteroid (11-beta) dehydrogenase 2
- Symbol
- hsd11b2 Nomenclature History
- Previous Names
-
- wu:fi31d01
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity. Acts upstream of or within cortisol metabolic process and multicellular organismal response to stress. Predicted to be located in membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; endocrine system; and eye. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77132 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Theodoridi et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-hsd11b2 | Zebrafish Nomenclature Committee | |
CRISPR2-hsd11b2 | (3) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
apparent mineralocorticoid excess syndrome | Alliance | Apparent mineralocorticoid excess | 218030 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase, conserved site | Short-chain dehydrogenase/reductase SDR |
---|---|---|---|---|---|
UniProtKB:F1QLP1 | InterPro | 414 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hsd11b2-201
(1)
|
Ensembl | 2,592 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-189N10 | ZFIN Curated Data | |
Encodes | EST | fi31d01 | ||
Encodes | cDNA | MGC:77132 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_212720 (1) | 2559 nt | ||
Genomic | GenBank:CR356247 (1) | 211785 nt | ||
Polypeptide | UniProtKB:F1QLP1 (1) | 414 aa |
- Castillo-Ramírez, L.A., Herget, U., Ryu, S., De Marco, R.J. (2024) Early-life challenge enhances cortisol regulation in zebrafish larvae. Biology Open. 13(12):
- Choi, M.K., Cook, A., Mungikar, K., Eachus, H., Tochwin, A., Linke, M., Gerber, S., Ryu, S. (2024) Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood. iScience. 27:110160110160
- Huang, J., Sun, C., Huang, Z., Zhu, Y., Chen, S.X. (2024) Upregulation of coagulation factor V by glucocorticoid in the preovulatory follicles of zebrafish. The Journal of steroid biochemistry and molecular biology. 241:106521
- Rajeswari, J.J., Faught, E., Santos, H., Vijayan, M.M. (2024) Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin. Journal of Cellular Physiology. 239(12):e31428
- Zhu, M., Li, Y., Shen, Q., Gong, Z., Liu, D. (2024) Sex disparity in zebrafish liver cell proliferation after partial hepatectomy is regulated by sex hormone receptors and the S100A1-YAP signaling cascade. Disease models & mechanisms. 17(10):
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
- Lim, M.Y., Bernier, N.J. (2023) Intergenerational plasticity to cycling high temperature and hypoxia affects offspring stress responsiveness and tolerance in zebrafish. The Journal of experimental biology. 226(16):
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Lim, M.Y., Bernier, N.J. (2022) Zebrafish parental progeny investment in response to cycling thermal stress and hypoxia: deposition of heat shock proteins but not cortisol. The Journal of experimental biology. 225(21):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
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