Gene
calm3a
- ID
- ZDB-GENE-030131-5590
- Name
- calmodulin 3a (phosphorylase kinase, delta)
- Symbol
- calm3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Is expressed in heart. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and long QT syndrome 16. Orthologous to human CALM3 (calmodulin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gou et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| long QT syndrome 16 | Alliance | Long QT syndrome 16 | 618782 |
| long QT syndrome 16 | Alliance | ?Ventricular tachycardia, catecholaminergic polymorphic 6 | 618782 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calmodulin/Myosin light chain/Troponin C-like | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|---|
| UniProtKB:B2GQW3 | InterPro | 149 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
calm3a-203
(1)
|
Ensembl | 2,145 nt | ||
| mRNA |
calm3a-204
(1)
|
Ensembl | 450 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-242K11 | ZFIN Curated Data | |
| Contained in | BAC | CH211-261A10 | ZFIN Curated Data | |
| Encodes | EST | fi05b08 | ||
| Encodes | cDNA | MGC:55296 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86728 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192068 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182967 (1) | 2180 nt | ||
| Genomic | GenBank:BX927291 (2) | 154479 nt | ||
| Polypeptide | UniProtKB:B2GQW3 (1) | 149 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CALM3 | 19 | Nucleotide sequence comparison (1) |
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Gou, D., Zhou, J., Song, Q., Wang, Z., Bai, X., Zhang, Y., Zuo, M., Wang, F., Chen, A., Yousaf, M., Yang, Z., Peng, H., Li, K., Xie, W., Tang, J., Yao, Y., Han, M., Ke, T., Chen, Q., Xu, C., Wang, Q. (2020) Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5-cryab-hspb2 signaling in zebrafish. Acta physiologica (Oxford, England). 231(3):e13567
- Qiu, L., Jia, K., Huang, L., Liao, X., Guo, X., Lu, H. (2019) Hepatotoxicity of tricyclazole in zebrafish (Danio rerio). Chemosphere. 232:171-179
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Bugel, S.M., Wehmas, L.C., La Du, J.K., Tanguay, R.L. (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicology and applied pharmacology. 296:31-41
- Purushothaman, S., Saxena, S., Meghah, V., Meena Lakshmi, M.G., Singh, S.K., Brahmendra Swamy, C.V., Idris, M.M. (2015) Proteomic and gene expression analysis of zebrafish brain undergoing continuous light/dark stress. Journal of sleep research. 24(4):458-65
- Krens, S.F., Corredor-Adamez, M., He, S., Snaar-Jagalska, B.E., and Spaink, H.P. (2008) ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. BMC Genomics. 9:196
- Friedberg, F., and Taliaferro, L (2005) Calmodulin genes in zebrafish (revisited). Molecular biology reports. 32(1):55-60
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
- Friedberg, F. and Rhoads, A.R. (2002) Multiple calmodulin genes in fish. Molecular biology reports. 29(4):377-382
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