Gene
eif2s3
- ID
- ZDB-GENE-030131-5552
- Name
- eukaryotic translation initiation factor 2, subunit 3 gamma
- Symbol
- eif2s3 Nomenclature History
- Previous Names
-
- eukaryotic translation initiation factor 2 gamma (1)
- fi03g03
- wu:fi03g03
- wu:fi37d04
- zgc:63805
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable methionyl-initiator methionine tRNA binding activity and translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to act upstream of or within translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63805 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hi929Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
hi969Tg | Transgenic insertion | 5' UTR | Unknown | DNA | |
hi3689Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
la028599Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
MEHMO syndrome | Alliance | MEHMO syndrome | 300148 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
Domain | IPR015256 | Initiation factor eIF2 gamma, C-terminal |
Domain | IPR044127 | Initiation factor eIF2 gamma, domain 2 |
Domain | IPR044128 | Initiation factor eIF2 gamma, GTP-binding domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | Eukaryotic Initiation Factor 2 Gamma Subunit | Initiation factor eIF2 gamma, C-terminal | Initiation factor eIF2 gamma, domain 2 | Initiation factor eIF2 gamma, GTP-binding domain | P-loop containing nucleoside triphosphate hydrolase | Translational (tr)-type GTP-binding domain | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal | Translation elongation factor EFTu-like, domain 2 | Translation protein, beta-barrel domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1QGW6 | InterPro | 472 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
eif2s3-201
(1)
|
Ensembl | 2,112 nt | ||
mRNA |
eif2s3-202
(1)
|
Ensembl | 839 nt | ||
mRNA |
eif2s3-203
(1)
|
Ensembl | 884 nt | ||
ncRNA |
eif2s3-004
(1)
|
Ensembl | 274 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-30N5 | ZFIN Curated Data | |
Encodes | EST | fi03g03 | ||
Encodes | EST | fi37d04 | ZFIN Curated Data | |
Encodes | cDNA | MGC:63805 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_212711 (1) | 2015 nt | ||
Genomic | GenBank:BX469922 (1) | 200409 nt | ||
Polypeptide | UniProtKB:F1QGW6 (1) | 472 aa |
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Moortgat, S., Désir, J., Benoit, V., Boulanger, S., Pendeville, H., Nassogne, M.C., Lederer, D., Maystadt, I. (2016) Two novel EIF2S3 mutations associated with syndromic intellectual disability with severe microcephaly, growth retardation, and epilepsy. American journal of medical genetics. Part A. 170(11):2927-2933
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Kohn, M., Hogel, J., Vogel, W., Minich, P., Kehrer-Sawatzki, H., Graves, J.A., and Hameister, H. (2006) Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Trends in genetics : TIG. 22(4):203-210
- Rapkins, R.W., Hore, T., Smithwick, M., Ager, E., Pask, A.J., Renfree, M.B., Kohn, M., Hameister, H., Nicholls, R.D., Deakin, J.E., and Graves, J.A. (2006) Recent assembly of an imprinted domain from non-imprinted components. PLoS Genetics. 2(10):e182
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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