Gene

polr1a

ID
ZDB-GENE-030131-5286
Name
RNA polymerase I subunit A
Symbol
polr1a Nomenclature History
Previous Names
  • fa26a03
  • sb:cb935
  • wu:fa26a03
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable DNA binding activity and nucleotidyltransferase activity. Predicted to contribute to DNA-directed RNA polymerase activity. Acts upstream of or within embryonic viscerocranium morphogenesis; neural crest cell development; and rRNA transcription. Predicted to be located in chromosome and nucleolus. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including alar plate midbrain region; digestive system; nervous system; pectoral fin musculature; and segmental plate. Used to study acrofacial dysostosis Cincinnati type. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Orthologous to human POLR1A (RNA polymerase I subunit A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hi3639TgTransgenic insertion5' UTRUnknownDNA
la012505TgTransgenic insertionUnknownUnknownDNA
sa1376Allele with one point mutationUnknownPremature StopENU
sa2745Allele with one point mutationDonor Splice SiteSplice SiteENU
sa12570Allele with one point mutationUnknownPremature StopENU
sa22458Allele with one point mutationUnknownSplice SiteENU
sa22459Allele with one point mutationUnknownPremature StopENU
sa22460Allele with one point mutationUnknownPremature StopENU
sa45512Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With polr1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrofacial dysostosis Cincinnati type Alliance Acrofacial dysostosis, Cincinnati type 616462
Leukodystrophy, hypomyelinating, 27 620675
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Associated With polr1a Via Experimental Models
Human Disease Fish Conditions Citations
acrofacial dysostosis Cincinnati type polr1ahi3639Tg/hi3639Tg control Watt et al., 2018
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000722 RNA polymerase, alpha subunit
Domain IPR006592 RNA polymerase, N-terminal
Domain IPR007066 RNA polymerase Rpb1, domain 3
Domain IPR007080 RNA polymerase Rpb1, domain 1
Domain IPR007081 RNA polymerase Rpb1, domain 5
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Domain Details Per Protein
Protein Additional Resources Length DNA-directed RNA pol I, largest subunit, C-terminal domain DNA-directed RNA pol I, largest subunit, N-terminal domain DNA-directed RNA polymerase, subunit beta-prime RNA polymerase, alpha subunit RNA polymerase, N-terminal RNA polymerase Rpb1, clamp domain superfamily RNA polymerase Rpb1, domain 1 RNA polymerase Rpb1, domain 3 RNA polymerase Rpb1, domain 3 superfamily RNA polymerase Rpb1, domain 4 RNA polymerase Rpb1, domain 5 RNA polymerase Rpb1, funnel domain superfamily
UniProtKB:A0A0R4I9V4 InterPro 1693
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 14
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA polr1a-201 (1) Ensembl 5,286 nt
mRNA polr1a-202 (1) Ensembl 7,583 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-87E17ZFIN Curated Data
Contained inBACCH211-2M15ZFIN Curated Data
EncodesESTcb935ZFIN Curated Data
EncodesESTfa26a03
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPOLR1A2
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
MousePolr1a6
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 10
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