Gene
hspb9l
- ID
- ZDB-GENE-030131-5148
- Name
- heat shock protein, alpha-crystallin-related, b9-like
- Symbol
- hspb9l Nomenclature History
- Previous Names
-
- hspb11 (1)
- cb02d06
- mg:cb02d06
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable unfolded protein binding activity. Acts upstream of or within myosin filament organization. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adaxial cell; brain; horizontal myoseptum; pericardial region; and somite.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Klüver et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hspb9l | N/A | Klüver et al., 2011 |
| MO2-hspb9l | N/A | Klüver et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha crystallin/Hsp20 domain | Alpha crystallin/Small heat shock protein, animal type | HSP20-like chaperone |
|---|---|---|---|---|---|
| UniProtKB:A5JV83 | InterPro | 205 | |||
| UniProtKB:A0A0R4I9A8 | InterPro | 205 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hspb11-201
(1)
|
Ensembl | 1,042 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(hspb9l:EGFP) |
|
| 1 | Shahid et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30K6 | ZFIN Curated Data | |
| Encodes | EST | cb02d06 | ||
| Encodes | cDNA | MGC:194222 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194237 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001099427 (1) | 938 nt | ||
| Genomic | GenBank:AL844141 (1) | 257634 nt | ||
| Polypeptide | UniProtKB:A0A0R4I9A8 (1) | 205 aa |
No data available
- Gaur, H., Bhargava, A. (2019) Glyphosate induces toxicity and modulates calcium and NO signaling in zebrafish embryos. Biochemical and Biophysical Research Communications. 513(4):1070-1075
- Shields, J.N., Hales, E.C., Ranspach, L.E., Luo, X., Orr, S., Runft, D., Dombkowski, A., Neely, M.N., Matherly, L.H., Taub, J., Baker, T.R., Thummel, R. (2019) Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11. Toxics. 7(4):
- Burkhard, S.B., Bakkers, J. (2018) Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate. eLIFE. 7
- Mercer, E.J., Lin, Y.F., Cohen-Gould, L., Evans, T. (2018) Hspb7 is a Cardioprotective Chaperone Facilitating Sarcomeric Proteostasis. Developmental Biology. 435(1):41-55
- Zhang, R., Wang, X., Zhang, X., Zhang, J., Zhang, X., Shi, X., Crump, D., Letcher, R.J., Giesy, J.P., Liu, C. (2018) Down-Regulation of hspb9 and hspb11 Contributes to Wavy Notochord in Zebrafish Embryos Following Exposure to Polychlorinated Diphenylsulfides. Environmental science & technology. 52(21):12829-12840
- Faria, M., Prats, E., Padrós, F., Soares, A.M., Raldúa, D. (2017) Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication. Archives of toxicology. 91(4):1891-1901
- Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016) Zebrafish biosensor for toxicant induced muscle hyperactivity. Scientific Reports. 6:23768
- Singh, A.R., Sivadas, A., Sabharwal, A., Vellarikal, S.K., Jayarajan, R., Verma, A., Kapoor, S., Joshi, A., Scaria, V., Sivasubbu, S. (2016) Chamber Specific Gene Expression Landscape of the Zebrafish Heart. PLoS One. 11:e0147823
- Büttner, A., Busch, W., Klüver, N., Giannis, A., and Scholz, S. (2012) Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine. Reproductive toxicology (Elmsford, N.Y.). 33(2):254-263
- Klüver, N., Yang, L., Busch, W., Scheffler, K., Renner, P., Strähle, U., and Scholz, S. (2011) Transcriptional Response of Zebrafish Embryos Exposed to Neurotoxic Compounds Reveals a Muscle Activity Dependent hspb11 Expression. PLoS One. 6(12):e29063
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