Gene

prpf4

ID
ZDB-GENE-030131-5143
Name
pre-mRNA splicing tri-snRNP complex factor PRPF4
Symbol
prpf4 Nomenclature History
Previous Names
  • mg:ab03a02
  • zgc:65943
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable U4 snRNA binding activity and U6 snRNA binding activity. Acts upstream of or within chordate embryonic development; mRNA splicing, via spliceosome; and sensory system development. Predicted to be located in nuclear speck. Predicted to be part of U4/U6 x U5 tri-snRNP complex. Is expressed in brain; eye; head; posterior lateral line primordium; and spinal cord. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa33729Allele with one point mutationUnknownSplice SiteENU
tsu5isAllele with one insertionExon 3UnknownCRISPR
tsu243TgTransgenic insertionUnknownUnknownDNA
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Sequence Targeting Reagents
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Human Disease
Associated With prpf4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 70 Alliance Retinitis pigmentosa 70 615922
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Associated With prpf4 Via Experimental Models
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR014906 Pre-mRNA processing factor 4 (PRP4)-like
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036285 PRP4-like superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length G-protein beta WD-40 repeat Pre-mRNA processing factor 4 (PRP4)-like PRP4-like superfamily WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q6PH45 InterPro 507
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 5
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prpf4-201 (1) Ensembl 1,812 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPRPF49
Functional complementation (1)
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
MousePrpf44
Amino acid sequence comparison (1)
Citations
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