Gene
akt1s1
- ID
- ZDB-GENE-030131-482
- Name
- AKT1 substrate 1 (proline-rich)
- Symbol
- akt1s1 Nomenclature History
- Previous Names
-
- wu:fb34a04
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be involved in negative regulation of TORC1 signaling. Predicted to act upstream of or within negative regulation of TOR signaling and neurotrophin TRK receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in eye and male organism. Orthologous to human AKT1S1 (AKT1 substrate 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Proline-rich AKT1 substrate 1, N-terminal domain | Proline-rich AKT1 substrate 1 protein |
---|---|---|---|---|
UniProtKB:E7EY34 | InterPro | 354 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
akt1s1-201
(1)
|
Ensembl | 2,379 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_687419 (1) | 2289 nt | ||
Genomic | GenBank:BX005066 (1) | 172909 nt | ||
Polypeptide | UniProtKB:E7EY34 (1) | 354 aa |
- Muscò, A., Martini, D., Digregorio, M., Broccoli, V., Andreazzoli, M. (2024) Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development. Genes. 15(4):
- Thakuri, L.S., Park, C.M., Park, J.W., Rhyu, D.Y. (2023) Gracilaria chorda subcritical-water extracts as ameliorant of insulin resistance induced by high-glucose in zebrafish and dexamethasone in L6 myotubes. Journal of traditional and complementary medicine. 14:829082-90
- Md Razip, N.N., Mohd Noor, S., Norazit, A., Nordin, N., Sakeh, N.M., Khaza'ai, H. (2022) An Association between Insulin Resistance and Neurodegeneration in Zebrafish Larval Model (Danio rerio). International Journal of Molecular Sciences. 23(15)
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Gong, L., Zhou, H., Wang, C., He, L., Guo, C., Peng, C., Li, Y. (2021) Hepatoprotective effect of Forsythiaside A against acetaminophen-induced liver injury in zebrafish: coupling network pharmacology with biochemical pharmacology. Journal of ethnopharmacology. 271:113890
- Mawed, S.A., He, Y., Zhang, J., Mei, J. (2020) Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish. International Journal of Molecular Sciences. 21(4):
- Mazumder, A.G., Kumari, S., Singh, D. (2019) Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. Epilepsy Research. 157:106207
- Quan, Y., Gong, L., He, J., Zhou, Y., Liu, M., Cao, Z., Li, Y., Peng, C. (2019) Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Toxicology letters. 306:66-79
- Tanwar, G., Mazumder, A.G., Bhardwaj, V., Kumari, S., Bharti, R., Yamini, ., Singh, D., Das, P., Purohit, R. (2019) Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures. Scientific Reports. 9:7904
- Xia, W., Hu, J., Ma, J., Huang, J., Jing, T., Deng, L., Zhang, J., Jiang, N., Ma, D., Ma, Z. (2019) Mutations in TOP2B cause autosomal-dominant hereditary hearing loss via inhibition of the PI3K-Akt signalling pathway. FEBS letters. 593(15):2008-2018
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