Gene
plxna4
- ID
- ZDB-GENE-030131-4663
- Name
- plexin A4
- Symbol
- plxna4 Nomenclature History
- Previous Names
-
- wu:fd49b01
- wu:fe15f03
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable semaphorin receptor activity. Acts upstream of or within axon guidance; axonal defasciculation; and morphogenesis of a branching structure. Predicted to be located in membrane. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including basal plate midbrain region; nervous system; optic vesicle; presumptive neural retina; and spinal cord neural tube. Orthologous to human PLXNA4 (plexin A4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2440 (16 images)
- eu1056 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ca307 | Allele with one delins | Exon 1 | Frameshift, Premature Stop | CRISPR | |
la024435Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la024437Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la024438Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028976Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la028977Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-plxna4 | van der Klaauw et al., 2019 | |
CRISPR2-plxna4 | van der Klaauw et al., 2019 | |
CRISPR3-plxna4 | (2) | |
MO1-plxna4 | N/A | (3) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin, cytoplasmic RasGAP domain | Plexin, cytoplasmic RhoGTPase-binding domain | Plexin family | Plexin repeat | Plexin, TIG domain 1 | Plexin, TIG domain 2 | PSI domain | Rho GTPase activation protein | Sema domain | Sema domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B3DK42 | InterPro | 1903 | ||||||||||||||
UniProtKB:Q6BEA0 | InterPro | 1903 | ||||||||||||||
UniProtKB:T1ECS6 | InterPro | 1903 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
plxna4-201
(1)
|
Ensembl | 8,676 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-98L9 | ZFIN Curated Data | |
Contained in | BAC | DKEY-247M22 | ZFIN Curated Data | |
Encodes | EST | eu1056 | Thisse et al., 2005 | |
Encodes | EST | eu2440 | Thisse et al., 2005 | |
Encodes | EST | fd49b01 | ||
Encodes | EST | fe15f03 | ||
Encodes | EST | wz10875 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194791 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001004495 (1) | 5712 nt | ||
Genomic | GenBank:BX537358 (1) | 230105 nt | ||
Polypeptide | UniProtKB:B3DK42 (1) | 1903 aa |
- Nurcombe, Z.W., Hehr, C.L., McFarlane, S. (2023) Plexina4 and cell survival in the developing zebrafish hindbrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(11):1323-1337
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Takamiya, M., Stegmaier, J., Kobitski, A.Y., Schott, B., Weger, B.D., Margariti, D., Cereceda Delgado, A.R., Gourain, V., Scherr, T., Yang, L., Sorge, S., Otte, J.C., Hartmann, V., van Wezel, J., Stotzka, R., Reinhard, T., Schlunck, G., Dickmeis, T., Rastegar, S., Mikut, R., Nienhaus, G.U., Strähle, U. (2020) Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genetics. 16:e1008774
- van der Klaauw, A.A., Croizier, S., Mendes de Oliveira, E., Stadler, L.K.J., Park, S., Kong, Y., Banton, M.C., Tandon, P., Hendricks, A.E., Keogh, J.M., Riley, S.E., Papadia, S., Henning, E., Bounds, R., Bochukova, E.G., Mistry, V., O'Rahilly, S., Simerly, R.B., INTERVAL, UK10K Consortium, Minchin, J.E.N., Barroso, I., Jones, E.Y., Bouret, S.G., Farooqi, I.S. (2019) Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 176(4):729-742.e18
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Emerson, S.E., Light, S.E., Ebert, A.M. (2017) Neuronal expression patterns of the PlexinA family during zebrafish development. Gene expression patterns : GEP. 27:56-66
- Xiao, B., Cui, L.Q., Ding, C., Wang, H. (2017) Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Zebrafish. 14(3):209-215
- Barton, R., Khakbaz, P., Bera, I., Klauda, J.B., Iovine, M.K., Berger, B.W. (2016) Interplay of specific trans- and juxtamembrane interfaces in Plexin A3 dimerization and signal transduction. Biochemistry. 55(35):4928-38
- Cardoso, J.C., Bergqvist, C.A., Felix, R.C., Larhammar, D. (2016) Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Journal of molecular endocrinology. 57(1):73-86
- Yoo, S.K., Pascoe, H.G., Pereira, T., Kondo, S., Jacinto, A., Zhang, X., Hariharan, I.K. (2016) Plexins function in epithelial repair in both Drosophila and zebrafish. Nature communications. 7:12282
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