Gene
f2
- ID
- ZDB-GENE-030131-4606
- Name
- coagulation factor II (thrombin)
- Symbol
- f2 Nomenclature History
- Previous Names
-
- prothrombin (1)
- wu:fb57c10
- wu:fd42e09
- wu:fd59d01
- zgc:66319
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including appendicitis; artery disease (multiple); autoimmune disease (multiple); hemophilia (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903359 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebral infarction | Alliance | {Stroke, ischemic, susceptibility to} | 601367 |
| prothrombin deficiency | Alliance | Dysprothrombinemia | 613679 |
| prothrombin deficiency | Alliance | Hypoprothrombinemia | 613679 |
| prothrombin thrombophilia | Alliance | Thrombophilia 1 due to thrombin defect | 188050 |
| thrombophilia due to thrombin defect | Alliance | Thrombophilia 1 due to thrombin defect | 188050 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000294 | Gamma-carboxyglutamic acid-rich (GLA) domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Coagulation factor-like, Gla domain superfamily | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1A, coagulation factor VII/IX/X/C/Z | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Prothrombin/thrombin | Serine Protease S1 Domain-Containing Protein | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site | Thrombin light chain | Thrombin light chain domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SXH8 | InterPro | 524 | ||||||||||||||||||
| UniProtKB:E7FAN5 | InterPro | 635 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-23N7 | ZFIN Curated Data | |
| Contains | SNP | rs3728083 | ZFIN Curated Data | |
| Encodes | EST | fb57c10 | ||
| Encodes | EST | fd42e09 | ||
| Encodes | EST | fd59d01 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6903359 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:66319 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213390 (1) | 1709 nt | ||
| Genomic | GenBank:BX957256 (1) | 227909 nt | ||
| Polypeptide | UniProtKB:E7FAN5 (1) | 635 aa |
- Ku, C.J., Yu, X., Zhao, Q.Y., Grzegorski, S.J., Daniel, J.G., Ferguson, A.C., Shavit, J.A. (2024) Loss of protein C vs protein S results in discrepant thrombotic phenotypes. Blood advances. :
- Zhang, H., Sun, C., Xia, Q., Li, P., Liu, K., Zhang, Y. (2024) Brevianamide F Exerts Antithrombotic Effects by Modulating the MAPK Signaling Pathway and Coagulation Cascade. Marine drugs. 22(10):
- Ma, X., Guo, R., Xu, H., Ma, Y., Zhang, R., Liu, X., Zhang, J., Han, Y. (2023) Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish. Journal of thrombosis and haemostasis : JTH. 22(4):951-964
- Wang, N., Lan, C., Lu, H., Li, L., Liao, D., Xu, K., Sun, H., Tang, Y., Wang, Y., Mei, J., Wei, M., Wu, T., Zhu, H. (2023) Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles. PLoS One. 18:e0285216e0285216
- Charlie-Silva, I., Feitosa, N.M., Pontes, L.G., Fernandes, B.H., Nóbrega, R.H., Gomes, J.M.M., Prata, M.N.L., Ferraris, F.K., Melo, D.C., Conde, G., Rodrigues, L.F., Aracati, M.F., Corrêa-Junior, J.D., Manrique, W.G., Superio, J., Garcez, A.S., Conceição, K., Yoshimura, T.M., Núñez, S.C., Eto, S.F., Fernandes, D.C., Freitas, A.Z., Ribeiro, M.S., Nedoluzhko, A., Lopes-Ferreira, M., Borra, R.C., Barcellos, L.J.G., Perez, A.C., Malafaia, G., Cunha, T.M., Belo, M.A.A., Galindo-Villegas, J. (2022) Plasma proteome responses in zebrafish following λ-carrageenan-Induced inflammation are mediated by PMN leukocytes and correlate highly with their human counterparts. Frontiers in immunology. 13:1019201
- Grzegorski, S.J., Zhao, Y., Richter, C.E., Ku, C.J., Lavik, K.I., Paul, D., Morrissey, J.H., Shavit, J.A. (2022) Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis. PLoS Genetics. 18:e1010534e1010534
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Wang, Y., Wu, H., Sheng, H., Wang, Y., Li, X., Wang, Y., Zhao, L. (2022) Discovery of anti-stroke active substances in Guhong injection based on multi-phenotypic screening of zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 155:113744
- Zhu, H., Lan, C., Zhao, D., Wang, N., Du, D., Luo, H., Lu, H., Peng, Z., Wang, Y., Qiao, Z., Huang, Y., Sun, B. (2022) Wuliangye Baijiu but not ethanol reduces cardiovascular disease risks in a zebrafish thrombosis model. NPJ science of food. 6:5555
- Li, J., Liu, H., Yang, Z., Yu, Q., Zhao, L., Wang, Y. (2021) Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish. Frontiers in pharmacology. 11:622787
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