Gene
anln
- ID
- ZDB-GENE-030131-4486
- Name
- anillin, actin binding protein
- Symbol
- anln Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within asymmetric cell division; glomerular filtration; and glomerulus development. Predicted to be located in bleb. Predicted to be active in actomyosin contractile ring. Is expressed in brain; eye; optic cup; optic tectum; and retina. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa45680 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-anln | (2) | |
| CRISPR2-anln | Mooney et al., 2019 | |
| MO1-anln | N/A | (2) |
| MO2-anln | N/A | (2) |
| MO3-anln | N/A | Gbadegesin et al., 2014 |
| MO4-anln | N/A | Hall et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| focal segmental glomerulosclerosis 8 | Alliance | Focal segmental glomerulosclerosis 8 | 616032 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Anillin homology domain | Anillin, N-terminal domain | Anillin, PH domain | Cytokinesis and Rho signaling-related protein | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A286Y917 | InterPro | 1171 | ||||||
| UniProtKB:F1QJH8 | InterPro | 1153 | ||||||
| UniProtKB:A0AB32TBF8 | InterPro | 1152 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197N10 | ZFIN Curated Data | |
| Encodes | EST | fb74d05 | ||
| Encodes | EST | fd10d09 | ||
| Encodes | EST | fi41f04 | ||
| Encodes | cDNA | MGC:158365 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001102676 (1) | 5182 nt | ||
| Genomic | GenBank:BX957241 (1) | 199001 nt | ||
| Polypeptide | UniProtKB:A0A286Y917 (1) | 1171 aa |
- Olson, H.M., Maxfield, A., Calistri, N.L., Heiser, L.M., Qian, W., Knaut, H., Nechiporuk, A.V. (2024) RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Development (Cambridge, England). 151(1):
- Qian, W., Yamaguchi, N., Lis, P., Cammer, M., Knaut, H. (2023) Pulses of RhoA signaling stimulate actin polymerization and flow in protrusions to drive collective cell migration. Current biology : CB. 34(2):245-259.e8
- Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M., Junker, J.P. (2021) Spatio-temporal mRNA tracking in the early zebrafish embryo. Nature communications. 12:3358
- Covello, G., Rossello, F.J., Filosi, M., Gajardo, F., Duchemin, A.L., Tremonti, B.F., Eichenlaub, M., Polo, J.M., Powell, D., Ngai, J., Allende, M.L., Domenici, E., Ramialison, M., Poggi, L. (2020) Transcriptome analysis of the zebrafish atoh7-/- Mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases. FASEB bioAdvances. 2:434-448
- Mooney, M.R., Davis, E.E., Katsanis, N. (2019) Analysis of Single Nucleotide Variants in CRISPR-Cas9 Edited Zebrafish Exomes Shows No Evidence of Off-Target Inflation. Frontiers in genetics. 10:949
- Hall, G., Lane, B.M., Khan, K., Pediaditakis, I., Xiao, J., Wu, G., Wang, L., Kovalik, M.E., Chryst-Stangl, M., Davis, E.E., Spurney, R.F., Gbadegesin, R.A. (2018) The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.. Journal of the American Society of Nephrology : JASN. 29(8):2110-2122
- Cepero Malo, M., Duchemin, A.L., Guglielmi, L., Patzel, E., Sel, S., Auffarth, G.U., Carl, M., Poggi, L. (2017) The Zebrafish Anillin-eGFP Reporter Marks Late Dividing Retinal Precursors and Stem Cells Entering Neuronal Lineages. PLoS One. 12:e0170356
- Goldman, J.A., Kuzu, G., Lee, N., Karasik, J., Gemberling, M., Foglia, M.J., Karra, R., Dickson, A.L., Sun, F., Tolstorukov, M.Y., Poss, K.D. (2017) Resolving Heart Regeneration by Replacement Histone Profiling. Developmental Cell. 40:392-404.e5
- Anderson, B.R., Howell, D.N., Soldano, K., Garrett, M.E., Katsanis, N., Telen, M.J., Davis, E.E., Ashley-Koch, A.E. (2015) In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. PLoS Genetics. 11:e1005349
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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