Gene
anxa2a
- ID
- ZDB-GENE-030131-4282
- Name
- annexin A2a
- Symbol
- anxa2a Nomenclature History
- Previous Names
-
- wu:fc87g06
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be involved in cell adhesion. Predicted to be located in basement membrane and extracellular region. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in several structures, including EVL; gill; integument; notochord; and periderm. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77940 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb583 | Allele with one deletion | Exon 6 | Unknown | CRISPR | |
| ihb584 | Allele with one deletion | Exon 6 | Unknown | not specified | |
| ihb585 | Allele with one deletion | Exon 6 | Unknown | CRISPR | |
| sa10952 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24716 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25237 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38125 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Annexin | Annexin A2 | Annexin repeat | Annexin repeat, conserved site | Annexin superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q804G9 | InterPro | 337 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
anxa2a-201
(1)
|
Ensembl | 1,639 nt | ||
| mRNA |
anxa2a-202
(1)
|
Ensembl | 1,449 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-84K18 | ZFIN Curated Data | |
| Encodes | EST | fc87g06 | ||
| Encodes | cDNA | MGC:66006 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77940 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181761 (1) | 1464 nt | ||
| Genomic | GenBank:CT573383 (2) | 171217 nt | ||
| Polypeptide | UniProtKB:Q804G9 (1) | 337 aa |
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Kapuria, S., Bai, H., Fierros, J., Huang, Y., Ma, F., Yoshida, T., Aguayo, A., Kok, F., Wiens, K.M., Yip, J.K., McCain, M.L., Pellegrini, M., Nagashima, M., Hitchcock, P.F., Mochizuki, N., Lawson, N.D., Harrison, M.M.R., Lien, C.L. (2022) Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration. Development (Cambridge, England). 149(4):
- Brown, C., Mullins, L.J., Wesencraft, K., McConnell, G., Beltran, M., Henderson, N.C., Conway, B., Hoffmann, S., Rider, S., Mullins, J.J. (2021) scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 55:35-47
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Koth, J., Wang, X., Killen, A.C., Stockdale, W.T., Potts, H.G., Jefferson, A., Bonkhofer, F., Riley, P.R., Patient, R.K., Göttgens, B., Mommersteeg, M.T.M. (2020) Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration. Development (Cambridge, England). 147(8)
- Quoseena, M., Vuppaladadium, S., Hussain, S., Banu, S., Bharathi, S., Idris, M.M. (2020) Functional role of annexins in zebrafish caudal fin regeneration - A gene knockdown approach in regenerating tissue. Biochimie. 175:125-131
- Wierson, W.A., Welker, J.M., Almeida, M.P., Mann, C.M., Webster, D.A., Torrie, M.E., Weiss, T.J., Kambakam, S., Vollbrecht, M.K., Lan, M., McKeighan, K.C., Levey, J., Ming, Z., Wehmeier, A., Mikelson, C.S., Haltom, J.A., Kwan, K.M., Chien, C.B., Balciunas, D., Ekker, S.C., Clark, K.J., Webber, B.R., Moriarity, B.S., Solin, S.L., Carlson, D.F., Dobbs, D.L., McGrail, M., Essner, J. (2020) Efficient targeted integration directed by short homology in zebrafish and mammalian cells. eLIFE. 9:
- Bise, T., de Preux Charles, A.S., Jaźwińska, A. (2019) Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart. NPJ Regenerative medicine. 4:2
- Dooley, C.M., Wali, N., Sealy, I.M., White, R.J., Stemple, D.L., Collins, J.E., Busch-Nentwich, E.M. (2019) The gene regulatory basis of genetic compensation during neural crest induction. PLoS Genetics. 15:e1008213
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
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