Gene
src
- ID
- ZDB-GENE-030131-3809
- Name
- v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
- Symbol
- src Nomenclature History
- Previous Names
-
- fc54g04
- sb:cb864
- wu:fc54g04
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within posterior lateral line neuromast primordium migration; regulation of vascular permeability; and response to yeast. Predicted to be located in several cellular components, including focal adhesion; mitochondrial inner membrane; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including adaxial cell; central nervous system; musculature system; periderm; and retina. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb864 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa31093 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-src | Gallardo et al., 2015 | |
| CRISPR2-src | Gallardo et al., 2015 | |
| MO1-src | N/A | Jopling et al., 2005 |
| MO2-src | N/A | Hoeppner et al., 2012 |
| MO3-src | N/A | Turro et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colon cancer, advanced, somatic | 114500 |
| ?Thrombocytopenia 6 | 616937 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B2GS52 | InterPro | 534 | |||||||||||
| UniProtKB:A0A8M6YVT4 | InterPro | 543 | |||||||||||
| UniProtKB:Q1JPZ3 | InterPro | 534 | |||||||||||
| UniProtKB:A0A2R8QE56 | InterPro | 540 | |||||||||||
| UniProtKB:A0A8M6Z3N7 | InterPro | 549 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fabp10a:src,myl7:EGFP) |
|
| 2 | (10) | |
| Tg(mir194:casrc_Y528F-GFP) |
|
| 1 | (3) | |
| Tg(mir194:casrc_Y528F-mCherry) |
|
| 1 | (3) | |
| Tg(mir194:src-mChery) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-226F1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-79L8 | ZFIN Curated Data | |
| Encodes | EST | cb864 | Thisse et al., 2001 | |
| Encodes | EST | fc54g04 | ||
| Encodes | cDNA | MGC:136457 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192468 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003837 (1) | 2743 nt | ||
| Genomic | GenBank:BX548066 (2) | 185926 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z3N7 (1) | 549 aa |
- Hou, C.Y., Ma, C.Y., Lin, Y.J., Huang, C.L., Wang, H.D., Yuh, C.H. (2022) WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. International Journal of Molecular Sciences. 23(20):
- Liang, F., Zhang, Y., Li, L., Yang, Y., Fei, J.F., Liu, Y., Qin, W. (2022) SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish. Nature communications. 13:3421
- Wei, J., Wang, X., Dong, Y., Zhong, X., Ren, X., Song, R., Ma, J., Yu, A., Fan, Q., Yao, J., Shan, D., Lv, F., Zheng, Y., Deng, Q., Li, X., He, Y., Fan, S., Zhao, C., Wang, X., Yuan, R., She, G. (2022) Curcumae Rhizoma - combined with Sparganii Rhizoma in the treatment of liver cancer: Chemical analysis using UPLC-LTQ-Orbitrap MSn, network analysis, and experimental assessment. Frontiers in pharmacology. 13:10276871027687
- Lin, H.D., Tseng, Y.K., Yuh, C.H., Chen, S.C. (2021) Low concentrations of 4-ABP promote liver carcinogenesis in human liver cells and a zebrafish model. Journal of hazardous materials. 423:126954
- Vandestadt, C., Vanwalleghem, G.C., Khabooshan, M.A., Douek, A.M., Castillo, H.A., Li, M., Schulze, K., Don, E., Stamatis, S.A., Ratnadiwakara, M., Änkö, M.L., Scott, E.K., Kaslin, J. (2021) RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish. Developmental Cell. 56:2364-2380.e8
- Zheng, X., Zhang, K., Zhao, Y., Fent, K. (2021) Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans. Environment International. 149:106159
- Sie, Z.L., Li, R.Y., Sampurna, B.P., Hsu, P.J., Liu, S.C., Wang, H.D., Huang, C.L., Yuh, C.H. (2020) WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. Cancers. 12(3):
- Wu, S.Y., Yang, W.Y., Cheng, C.C., Hsiao, M.C., Tsai, S.L., Lin, H.K., Lin, K.H., Yuh, C.H. (2020) Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model. Cancers. 12(6):
- Wu, S.Y., Yang, W.Y., Cheng, C.C., Lin, K.H., Sampurna, B.P., Chan, S.M., Yuh, C.H. (2020) Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. Clinical and translational medicine. 10:e252
- Lin, H.S., Huang, Y.L., Wang, Y.S., Hsiao, E., Hsu, T.A., Shiao, H.Y., Jiaang, W.T., Sampurna, B.P., Lin, K.H., Wu, M.S., Lai, G.M., Yuh, C.H. (2019) Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index than Sorafenib via Zebrafish Drug Screening Platform. Cancers. 11(6)
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