Gene
dicer1
- ID
- ZDB-GENE-030131-3445
- Name
- dicer 1, ribonuclease type III
- Symbol
- dicer1 Nomenclature History
- Previous Names
-
- fc39d11
- fc74b05
- wu:fc39d11
- wu:fc74b05
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables pre-miRNA binding activity. Acts upstream of or within with a positive effect on pre-miRNA processing. Acts upstream of or within regulation of neurogenesis; regulatory ncRNA-mediated gene silencing; and ventricular system development. Predicted to be part of RISC complex and RISC-loading complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu715 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| hu894 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| hu896 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9205 | Allele with one point mutation | Exon 9 | Premature Stop | ENU | |
| sa11548 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19169 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dicer1 | N/A | (10) |
| MO2-dicer1 | N/A | Wienholds et al., 2003 |
| MO3-dicer1 | N/A | (3) |
| MO4-dicer1 | N/A | Ristori et al., 2015 |
| MO5-dicer1 | N/A | Ristori et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| DICER1 syndrome | Alliance | Pleuropulmonary blastoma | 601200 |
| multinodular goiter | Alliance | Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors | 138800 |
| GLOW syndrome, somatic mosaic | 618272 | ||
| Rhabdomyosarcoma, embryonal, 2 | 180295 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DEAD/DEAH box helicase domain | Dicer dimerisation domain | Dicer dimerisation domain superfamily | Dicer, double-stranded RNA-binding domain | Dicer, partner-binding domain | Dicer, platform domain | Double-stranded RNA-binding domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | PAZ domain | PAZ domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Ribonuclease III domain | Ribonuclease III, endonuclease domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6TV19 | InterPro | 1865 | ||||||||||||||
| UniProtKB:A0A8M9PNL3 | InterPro | 1865 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dicer1-201
(1)
|
Ensembl | 9,598 nt | ||
| mRNA |
dicer1-202
(1)
|
Ensembl | 6,123 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51K10 | ZFIN Curated Data | |
| Encodes | EST | fc39d11 | ||
| Encodes | EST | fc74b05 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161453 (1) | 9596 nt | ||
| Genomic | GenBank:BX004833 (1) | 216190 nt | ||
| Polypeptide | UniProtKB:A0A8M9PNL3 (1) | 1865 aa |
- Kretov, D.A., Folkes, L., Mora-Martin, A., Walawalkar, I.A., Imrat, ., Syedah, N., Vanuytsel, K., Moxon, S., Murphy, G.J., Cifuentes, D. (2024) The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis. Nature communications. 15:38213821
- Brown, W., Bardhan, A., Darrah, K., Tsang, M., Deiters, A. (2022) Optical Control of MicroRNA Function in Zebrafish Embryos. Journal of the American Chemical Society. 144(37):16819-16826
- Yu, W.X., Li, Y.K., Xu, M.F., Xu, C.J., Chen, J., Wei, Y.L., She, Z.Y. (2022) Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development. Cell death discovery. 8:490490
- Zhang, X., Yang, F., Liu, F., Tian, Q., Hu, M., Li, P., Zeng, Y. (2022) Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer. Frontiers in molecular biosciences. 8:730006
- Maerker, M., Getwan, M., Dowdle, M.E., McSheene, J.C., Gonzalez, V., Pelliccia, J.L., Hamilton, D.S., Yartseva, V., Vejnar, C., Tingler, M., Minegishi, K., Vick, P., Giraldez, A.J., Hamada, H., Burdine, R.D., Sheets, M.D., Blum, M., Schweickert, A. (2021) Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nature communications. 12:5482
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Kretov, D.A., Walawalkar, I.A., Mora-Martin, A., Shafik, A.M., Moxon, S., Cifuentes, D. (2020) Ago2-Dependent Processing Allows miR-451 to Evade the Global MicroRNA Turnover Elicited during Erythropoiesis. Molecular Cell. 78(2):317-328.e6
- Liu, Y., Zhu, Z., Ho, I.H.T., Shi, Y., Li, J., Wang, X., Chan, M.T.V., Cheng, C.H.K. (2020) Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Frontiers in genetics. 11:853
- Zhu, Z., Liu, Y., Xu, W., Liu, T., Xie, Y., Sham, K.W.Y., Sha, O., Cheng, C.H.K. (2020) Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Frontiers in genetics. 11:299
- Bremer, J., Marsden, K.C., Miller, A., Granato, M. (2019) The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons. Communications biology. 2:195
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