Gene

cul3a

ID
ZDB-GENE-030131-3376
Name
cullin 3a
Symbol
cul3a Nomenclature History
Previous Names
  • cul3
  • wu:fc37e01
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable ubiquitin protein ligase binding activity. Acts upstream of or within heart development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Edwards et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa18151Allele with one point mutationUnknownPremature StopENU
ya504Allele with one deletionExon 6UnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With cul3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
neurodevelopmental disorder with or without autism or seizures Alliance Neurodevelopmental disorder with or without autism or seizures 619239
Pseudohypoaldosteronism, type IIE 614496
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Associated With cul3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR016157 Cullin, conserved site
Domain IPR001373 Cullin, N-terminal
Domain IPR016158 Cullin homology domain
Domain IPR019559 Cullin protein, neddylation domain
Family IPR045093 Cullin
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Domain Details Per Protein
Protein Additional Resources Length Cullin Cullin, conserved site Cullin homology domain Cullin homology domain superfamily Cullin, N-terminal Cullin protein, neddylation domain Cullin repeat-like-containing domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F6NVK8 InterPro
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cul3a-201 (1) Ensembl 2,958 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-253N2ZFIN Curated Data
EncodesESTfc37e01
EncodescDNAMGC:77385ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCUL32
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseCul31
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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