Gene
hdac6
- ID
- ZDB-GENE-030131-3232
- Name
- histone deacetylase 6
- Symbol
- hdac6 Nomenclature History
- Previous Names
-
- wu:fc31d02
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables potassium ion binding activity; tubulin deacetylase activity; and zinc ion binding activity. Acts upstream of or within several processes, including hemopoiesis; regulation of tubulin deacetylation; and swimming behavior. Predicted to be located in several cellular components, including centrosome; dendrite; and perikaryon. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia and polycystic liver disease 1. Orthologous to human HDAC6 (histone deacetylase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la026686Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa18529 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa34293 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34294 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sh400 | Allele with one deletion | Unknown | Unknown | TALEN |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia | Alliance | ?Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia | 300863 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001607 | Zinc finger, UBP-type |
Domain | IPR023801 | Histone deacetylase domain |
Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Histone deacetylase domain | Histone deacetylase domain superfamily | Ureohydrolase domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, UBP-type |
---|---|---|---|---|---|---|---|
UniProtKB:F8W4B7 | InterPro PDB | 1081 | |||||
UniProtKB:A7YT55 | InterPro PDB | 929 |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-150E8 | ZFIN Curated Data | |
Contains | SNP | rs3728138 | ZFIN Curated Data | |
Contains | SNP | rs3728139 | ZFIN Curated Data | |
Contains | SNP | rs3728140 | ZFIN Curated Data | |
Encodes | EST | fc31d02 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_009303751 (1) | 4240 nt | ||
Genomic | GenBank:BX469901 (1) | 180553 nt | ||
Polypeptide | UniProtKB:F8W4B7 (1) | 1081 aa |
- Fischer, F., Schliehe-Diecks, J., Tu, J.W., Gangnus, T., Ho, Y.L., Hebeis, M., Alves Avelar, L.A., Scharov, K., Watrin, T., Kemkes, M., Stachura, P., Daugs, K., Biermann, L., Kremeyer, J., Horstick, N., Span, I., Pandyra, A.A., Borkhardt, A., Gohlke, H., Kassack, M.U., Burckhardt, B.B., Bhatia, S., Kurz, T. (2024) Deciphering the Therapeutic Potential of Novel Pentyloxyamide-Based Class I, IIb HDAC Inhibitors against Therapy-Resistant Leukemia. Journal of medicinal chemistry. 67(23):21223-21250
- Wang, P., Shi, W., Liu, S., Shi, Y., Jiang, X., Li, F., Chen, S., Sun, K., Xu, R. (2024) ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 51(9):934-946
- Pezzotta, A., Brioschi, L., Carbone, S., Mazzoleni, B., Bontempi, V., Monastra, F., Mauri, L., Marozzi, A., Mione, M., Pistocchi, A., Viani, P. (2023) Combined Inhibition of Hedgehog and HDAC6: In Vitro and In Vivo Studies Reveal a New Role for Lysosomal Stress in Reducing Glioblastoma Cell Viability. International Journal of Molecular Sciences. 24(6):
- Pezzotta, A., Gentile, I., Genovese, D., Totaro, M.G., Battaglia, C., Leung, A.Y., Fumagalli, M., Parma, M., Cazzaniga, G., Fazio, G., Alcalay, M., Marozzi, A., Pistocchi, A. (2022) HDAC6 inhibition decreases leukemic stem cell expansion driven by Hedgehog hyperactivation by restoring primary ciliogenesis. Pharmacological research. 183:106378
- Varga, J.K., Diffley, K., Welker Leng, K.R., Fierke, C.A., Schueler-Furman, O. (2022) Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates. Scientific Reports. 12:1788
- Volpatti, J.R., Ghahramani-Seno, M.M., Mansat, M., Sabha, N., Sarikaya, E., Goodman, S.J., Chater-Diehl, E., Celik, A., Pannia, E., Froment, C., Combes-Soia, L., Maani, N., Yuki, K.E., Chicanne, G., Uusküla-Reimand, L., Monis, S., Alvi, S.A., Genetti, C.A., Payrastre, B., Beggs, A.H., Bonnemann, C.G., Muntoni, F., Wilson, M.D., Weksberg, R., Viaud, J., Dowling, J.J. (2022) X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition. Acta Neuropathologica. 144(3):537-563
- Zhuang, M., Scholz, A., Walz, G., Yakulov, T.A. (2022) Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury. International Journal of Molecular Sciences. 23(17)
- Hosseinzadeh, P., Watson, P.R., Craven, T.W., Li, X., Rettie, S., Pardo-Avila, F., Bera, A.K., Mulligan, V.K., Lu, P., Ford, A.S., Weitzner, B.D., Stewart, L.J., Moyer, A.P., Di Piazza, M., Whalen, J.G., Greisen, P.J., Christianson, D.W., Baker, D. (2021) Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites. Nature communications. 12:3384
- Łysyganicz, P.K., Pooranachandran, N., Liu, X., Adamson, K.I., Zielonka, K., Elworthy, S., van Eeden, F.J., Grierson, A.J., Malicki, J.J. (2021) Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Frontiers in cell and developmental biology. 9:676214
- Olaoye, O.O., Watson, P.R., Nawar, N., Geletu, M., Sedighi, A., Bukhari, S., Raouf, Y.S., Manaswiyoungkul, P., Erdogan, F., Abdeldayem, A., Cabral, A.D., Hassan, M.M., Toutah, K., Shouksmith, A.E., Gawel, J.M., Israelian, J., Radu, T.B., Kachhiyapatel, N., de Araujo, E.D., Christianson, D.W., Gunning, P.T. (2021) Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of medicinal chemistry. 64(5):2691-2704
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