Gene

tpm4b

ID
ZDB-GENE-030131-2964
Name
tropomyosin 4b
Symbol
tpm4b Nomenclature History
Previous Names
  • TPM4-2 alpha (1)
  • wu:fc22f09
  • zgc:63734
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in actin filament. Is expressed in cardiovascular system; cephalic musculature; epiphysis; and otic vesicle. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human TPM4 (tropomyosin 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
No data available
Human Disease
Associated With tpm4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bleeding disorder, platelet-type, 25 620486
1 - 1 of 1
Associated With tpm4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000533 Tropomyosin
Homologous_superfamily IPR014751 DNA repair protein XRCC4-like, C-terminal
1 - 2 of 2
Domain Details Per Protein
Protein Additional Resources Length DNA repair protein XRCC4-like, C-terminal Tropomyosin
UniProtKB:A0A1L6UW65 InterPro 284
UniProtKB:Q7SXW1 InterPro 248
UniProtKB:A0A8M6Z082 InterPro 284
1 - 3 of 3
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 2
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tpm4b-201 (1) Ensembl 1,698 nt
mRNA tpm4b-203 (1) Ensembl 2,914 nt
mRNA tpm4b-204 (1) Ensembl 753 nt
ncRNA tpm4b-002 (1) Ensembl 691 nt
1 - 4 of 4
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-279P6ZFIN Curated Data
Contained inFosmidCH1073-323J21ZFIN Curated Data
EncodesESTfc22f09
EncodescDNAMGC:63734ZFIN Curated Data
1 - 4 of 4
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTPM419
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseTpm48
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 10 of 15
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