Gene
tpm4b
- ID
- ZDB-GENE-030131-2964
- Name
- tropomyosin 4b
- Symbol
- tpm4b Nomenclature History
- Previous Names
-
- TPM4-2 alpha (1)
- wu:fc22f09
- zgc:63734
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in actin filament. Is expressed in cardiovascular system; cephalic musculature; epiphysis; and otic vesicle. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human TPM4 (tropomyosin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63734 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Bleeding disorder, platelet-type, 25 | 620486 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | DNA repair protein XRCC4-like, C-terminal | Tropomyosin |
---|---|---|---|---|
UniProtKB:A0A1L6UW65 | InterPro | 284 | ||
UniProtKB:Q7SXW1 | InterPro | 248 | ||
UniProtKB:A0A8M6Z082 | InterPro | 284 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-279P6 | ZFIN Curated Data | |
Contained in | Fosmid | CH1073-323J21 | ZFIN Curated Data | |
Encodes | EST | fc22f09 | ||
Encodes | cDNA | MGC:63734 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199675 (1) | 3018 nt | ||
Genomic | GenBank:CU693492 (2) | 36714 nt | ||
Polypeptide | UniProtKB:A0A1L6UW65 (1) | 284 aa |
- Hofeichner, J., Gahr, B.M., Huber, M., Boos, A., Rottbauer, W., Just, S. (2023) CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo. Scientific Reports. 13:2267922679
- Lai, H.H., Yeh, K.Y., Hsu, H.M., Her, G.M. (2022) Deficiency of Adipose Triglyceride Lipase Induces Metabolic Syndrome and Cardiomyopathy in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Hu, M., Liu, P., Lu, S., Wang, Z., Lyu, Z., Liu, H., Sun, Y., Liu, F., Tian, J. (2021) Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish. Chinese Medicine. 16:119
- Tsedeke, A.T., Allanki, S., Gentile, A., Jimenez-Amilburu, V., Rasouli, S.J., Guenther, S., Lai, S.L., Stainier, D.Y.R., Marín-Juez, R. (2021) Cardiomyocyte heterogeneity during zebrafish development and regeneration. Developmental Biology. 476:259-271
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Liu, Y., Lin, Z., Liu, M., Liao, H., Chen, Y., Zhang, X., Chan, H.C., Zhou, B., Rao, L., Sun, H. (2020) CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy. Mechanisms of Development. 163:103627
- Whitesell, T.R., Chrystal, P.W., Ryu, J.R., Munsie, N., Grosse, A., French, C.R., Workentine, M.L., Li, R., Zhu, L.J., Waskiewicz, A., Lehmann, O.J., Lawson, N.D., Childs, S.J. (2019) foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish. Developmental Biology. 453(1):34-47
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Dube, D.K., Dube, S., Abbott, L., Wang, J., Fan, Y., Alshiekh-Nasany, R., Shah, K.K., Rudloff, A.P., Poiesz, B.J., Sanger, J.M., Sanger, J.W. (2017) Identification, characterization, and expression of sarcomeric tropomyosin isoforms in zebrafish. Cytoskeleton (Hoboken, N.J.). 74(3):125-142
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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