Gene
igf2b
- ID
- ZDB-GENE-030131-2935
- Name
- insulin-like growth factor 2b
- Symbol
- igf2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables insulin-like growth factor receptor binding activity. Acts upstream of or within several processes, including fin regeneration; somitogenesis; and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; digestive system; hypochord; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-igf2b | Zebrafish Nomenclature Committee | |
| CRISPR2-igf2b | Weiss et al., 2022 | |
| CRISPR3-igf2b | Zebrafish Nomenclature Committee | |
| MO1-igf2b | N/A | White et al., 2009 |
| MO2-igf2b | N/A | (2) |
| MO3-igf2b | N/A | (2) |
| MO4-igf2b | N/A | Chablais et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Silver-Russell syndrome 3 | 616489 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin, conserved site | Insulin-like | Insulin-like growth factor II | Insulin-like growth factor II E-peptide, C-terminal | Insulin-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JIE4 | InterPro | 212 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220G18 | ||
| Contained in | BAC | DKEY-217J16 | ||
| Encodes | EST | fc21h08 | ||
| Encodes | EST | fc34h12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001815 (1) | 3391 nt | ||
| Genomic | GenBank:AL954320 (1) | 215130 nt | ||
| Polypeptide | UniProtKB:Q8JIE4 (1) | 212 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Ka, Y., Lee, I., Ji, K. (2024) Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae. Ecotoxicology and environmental safety. 286:117170117170
- Rajeswari, J.J., Faught, E., Santos, H., Vijayan, M.M. (2024) Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin. Journal of Cellular Physiology. 239(12):e31428
- Heidary, S., Awasthi, N., Page, N., Allnutt, T., Lewis, R.S., Liongue, C., Ward, A.C. (2023) A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1). Cellular and molecular life sciences : CMLS. 80:109109
- Lau, E.S., Zhu, B., Sun, M.A., Ngai, S.M., Ge, W. (2023) Proteomic analysis of zebrafish Folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian Folliculogenesis. Biology of reproduction. 109(4):482-497
- Lin, C.Y., Yeh, K.Y., Lai, H.H., Her, G.M. (2023) AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish. Biomedicines. 11(2):
- Wei, Z., Bagivalu Lakshminarasimha, A., Cone, R., Michel, M. (2023) Loss of Agrp1 in zebrafish: Effects on the growth and reproductive axis. General and comparative endocrinology. 336:114243
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Kasica, N., Święch, A., Saładziak, K., Mackiewicz, J., Osęka, M. (2022) The Inhibitory Effect of Selected D2 Dopaminergic Receptor Agonists on VEGF-Dependent Neovascularization in Zebrafish Larvae: Potential New Therapy in Ophthalmic Diseases. Cells. 11(7):
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