Gene
add3a
- ID
- ZDB-GENE-030131-2721
- Name
- adducin 3 (gamma) a
- Symbol
- add3a Nomenclature History
- Previous Names
-
- add3
- wu:fb38g03
- wu:fc16e06
- zgc:55560
- zgc:77226
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Involved in actin filament organization and negative regulation of cardiac ventricle development. Acts upstream of or within hepaticobiliary system development. Predicted to be active in cytoskeleton; plasma membrane; and postsynaptic density. Is expressed in head; liver; pericardial region; and pleuroperitoneal region. Used to study biliary atresia. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 3. Orthologous to human ADD3 (adducin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spastic quadriplegic cerebral palsy 3 | Alliance | Cerebral palsy, spastic quadriplegic, 3 | 617008 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| biliary atresia | add3asa819/sa819 | standard conditions | Tang et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aldolase class II Adducin subfamily | Class II aldolase/adducin N-terminal | Class II aldolase/adducin N-terminal domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M6YXA3 | InterPro | 677 | |||
| UniProtKB:Q1LUP1 | InterPro | 672 | |||
| UniProtKB:A0A2R8QBF8 | InterPro | 671 | |||
| UniProtKB:Q1LUP2 | InterPro | 645 | |||
| UniProtKB:Q7ZUA1 | InterPro | 672 | |||
| UniProtKB:A0A8M6Z434 | InterPro | 651 | |||
| UniProtKB:A0A2R8Q5P5 | InterPro | 678 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
add3a-201
(1)
|
Ensembl | 2,502 nt | ||
| mRNA |
add3a-202
(1)
|
Ensembl | 3,671 nt | ||
| mRNA |
add3a-203
(1)
|
Ensembl | 3,494 nt | ||
| mRNA |
add3a-205
(1)
|
Ensembl | 871 nt | ||
| mRNA |
add3a-206
(1)
|
Ensembl | 612 nt | ||
| mRNA |
add3a-207
(1)
|
Ensembl | 570 nt | ||
| mRNA |
add3a-208
(1)
|
Ensembl | 2,044 nt | ||
| mRNA |
add3a-209
(1)
|
Ensembl | 2,148 nt | ||
| mRNA |
add3a-210
(1)
|
Ensembl | 2,661 nt | ||
| mRNA |
add3a-211
(1)
|
Ensembl | 2,261 nt | ||
| mRNA |
add3a-212
(1)
|
Ensembl | 3,034 nt | ||
| ncRNA |
add3a-005
(1)
|
Ensembl | 849 nt |
Interactions and Pathways
No data available
Plasmids
No data available