Gene
clint1a
- ID
- ZDB-GENE-030131-2590
- Name
- clathrin interactor 1a
- Symbol
- clint1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable clathrin binding activity and phospholipid binding activity. Acts upstream of or within regulation of epidermis development. Predicted to be located in cytoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Is expressed in epidermis and ventral fin fold. Orthologous to human CLINT1 (clathrin interactor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Dodd et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ENTH domain | ENTH/VHS |
|---|---|---|---|---|
| UniProtKB:Q6DRL7 | InterPro | 633 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
clint1a-201
(1)
|
Ensembl | 742 nt | ||
| mRNA |
clint1a-202
(1)
|
Ensembl | 3,401 nt | ||
| mRNA |
clint1a-203
(1)
|
Ensembl | 1,673 nt | ||
| mRNA |
clint1a-204
(1)
|
Ensembl | 5,342 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-147F20 | ZFIN Curated Data | |
| Contains | SNP | rs3728655 | ZFIN Curated Data | |
| Contains | SNP | rs3728656 | ZFIN Curated Data | |
| Contains | SNP | rs3728657 | ZFIN Curated Data | |
| Contains | SNP | rs3728658 | ZFIN Curated Data | |
| Contains | SNP | rs3728659 | ZFIN Curated Data | |
| Contains | SNP | rs3728660 | ZFIN Curated Data | |
| Contains | SNP | rs3728661 | ZFIN Curated Data | |
| Encodes | EST | fa05f05 | ZFIN Curated Data | |
| Encodes | EST | fb97f11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003412 (1) | 2364 nt | ||
| Genomic | GenBank:CR626866 (1) | 161413 nt | ||
| Polypeptide | UniProtKB:Q6DRL7 (1) | 633 aa |
- Hatzold, J., Nett, V., Brantsch, S., Zhang, J.L., Armistead, J., Wessendorf, H., Stephens, R., Humbert, P.O., Iden, S., Hammerschmidt, M. (2023) Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLoS Genetics. 19:e1010873e1010873
- Phatak, M., Sonawane, M. (2018) Functional characterisation of romeharsha and clint1 reaffirms the link between plasma membrane homeostasis, cell size maintenance and tissue homeostasis in developing zebrafish epidermis. Journal of biosciences. 43:605-619
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Deng, C., Chen, H., Yang, N., Feng, Y., Hsueh, A.J. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. The Journal of biological chemistry. 290(30):18261-8
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- LeBert, D.C., Squirrell, J.M., Rindy, J., Broadbridge, E., Lui, Y., Zakrzewska, A., Eliceiri, K.W., Meijer, A.H., Huttenlocher, A. (2015) Matrix metalloproteinase 9 modulates collagen matrices and wound repair. Development (Cambridge, England). 142(12):2136-46
- Danilova, N., Kumagai, A., and Lin, J. (2010) p53 Upregulation Is a Frequent Response to Deficiency of Cell-Essential Genes. PLoS One. 5(12):e15938
- Walters, K.B., Green, J.M., Surfus, J.C., Yoo, S.K., and Huttenlocher, A. (2010) Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome. Blood. 116(15):2803-2811
- Dodd, M.E., Hatzold, J., Mathias, J.R., Walters, K.B., Bennin, D.A., Rhodes, J., Kanki, J.P., Look, A.T., Hammerschmidt, M., and Huttenlocher, A. (2009) The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development (Cambridge, England). 136(15):2591-2600
- Kishi, S., Bayliss, P.E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D., Amsterdam, A., and Roberts, T.M. (2008) The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genetics. 4(8):e1000152
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