Gene
top2a
- ID
- ZDB-GENE-030131-2453
- Name
- DNA topoisomerase II alpha
- Symbol
- top2a Nomenclature History
- Previous Names
-
- fc08c07
- wu:fc08c07
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Acts upstream of or within animal organ regeneration and chromosome segregation. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; eye; midbrain; neural tube; and pectoral fin. Orthologous to human TOP2A (DNA topoisomerase II alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
cz4 | Allele with one point mutation | Intron 14 | Cryptic Splice Site, Frameshift, Premature Stop | ENU | |
hi3635Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
tju145 | Allele with one deletion | Exon 18 | Unknown | CRISPR | |
ucd3 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-top2a | Jin et al., 2021 | |
MO1-top2a | N/A | Dovey et al., 2009 |
MO2-top2a | N/A | Geng et al., 2022 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
DNA topoisomerase II, resistance to inhibition of, by amsacrine |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | C-terminal associated domain of TOPRIM | DNA topoisomerase 2, TOPRIM domain | DNA Topoisomerase II | DNA topoisomerase II, eukaryotic-type | DNA topoisomerase, type IIA | DNA topoisomerase, type IIA, alpha-helical domain superfamily | DNA topoisomerase, type IIA, conserved site | DNA topoisomerase, type IIA, domain A | DNA topoisomerase, type IIA, domain A, alpha-beta | DNA topoisomerase, type IIA-like domain superfamily | DNA topoisomerase, type IIA, subunit B, C-terminal | DNA topoisomerase, type IIA, subunit B, domain 2 | DTHCT | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | TOPRIM domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IUF0 | InterPro | 1570 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-120K20 | ZFIN Curated Data | |
Encodes | EST | fc08c07 | ||
Encodes | cDNA | MGC:92574 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192341 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001310015 (1) | 5539 nt | ||
Genomic | GenBank:BX470262 (2) | 164673 nt | ||
Polypeptide | UniProtKB:A0A0R4IUF0 (1) | 1570 aa |
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Xing, J., Chen, K., Gao, S., Pousse, M., Ying, Y., Wang, B., Chen, L., Wang, C., Wang, L., Hu, W., Lu, Y., Gilson, E., Ye, J. (2023) Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence. Aging Cell. 22(3):e13780
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
- Chen, J., Li, G., Lian, J., Ma, N., Huang, Z., Li, J., Wen, Z., Zhang, W., Zhang, Y. (2021) Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Science China. Life sciences. 64(12):2186-2201
- Duan, X.Y., Ma, R.J., Hsiao, C.D., Jiang, Z.Z., Zhang, L.Y., Zhang, Y., Liu, K.C. (2021) Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish. Chinese Journal of Natural Medicines. 19:750-757
- Jin, M., Li, J., Hu, R., Xu, B., Huang, G., Huang, W., Chen, B., He, J., Cao, Y. (2021) Cyclin A2/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 48(1):63-74
- Cosacak, M.I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., Kizil, C. (2019) Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cell Reports. 27:1307-1318.e3
- Liu, Q., Klingler, R.H., Wimpee, B., Dellinger, M., King-Heiden, T., Grzybowski, J., Gerstenberger, S.L., Weber, D.N., Caravan, M.J. (2016) Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 65:272-282
- Macaulay, I.C., Svensson, V., Labalette, C., Ferreira, L., Hamey, F., Voet, T., Teichmann, S.A., Cvejic, A. (2016) Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Cell Reports. 14(4):966-77
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