Gene
her8a
- ID
- ZDB-GENE-030131-2376
- Name
- hairy-related 8a
- Symbol
- her8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within gliogenesis and negative regulation of neurogenesis. Is active in chromatin. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; neural tube; and posterior neural keel.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85712 (17 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-her8a | N/A | Chung et al., 2011 |
| MO2-her8a | N/A | Chung et al., 2011 |
| MO3-her8a | N/A | Webb et al., 2011 |
| MO4-her8a | N/A | Webb et al., 2011 |
| MO5-her8a | N/A | Webb et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain |
|---|---|---|---|---|---|---|
| UniProtKB:F1R6H0 | InterPro | |||||
| UniProtKB:A0A8M2BJI1 | InterPro | 217 | ||||
| UniProtKB:F1QI81 | InterPro | 221 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199624 (1) | 1328 nt | ||
| Genomic | GenBank:CR848737 (1) | 158396 nt | ||
| Polypeptide | UniProtKB:F1QI81 (1) | 221 aa |
No data available
- Chen, H.Y., Huang, Y.C., Yeh, T.H., Chang, C.W., Shen, Y.J., Chen, Y.C., Sun, M.Q., Cheng, Y.C. (2024) Dtx2 deficiency induces ependymo-radial glial cell proliferation and improves spinal cord motor function recovery. Stem cells and development. 33(19-20):540-550
- Chen, Y.C., Hsieh, F.Y., Chang, C.W., Sun, M.Q., Cheng, Y.C. (2024) Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment. International Journal of Molecular Sciences. 25(17):
- England, S.J., Campbell, P.C., Banerjee, S., Bates, R.L., Grieb, G., Fancher, W.F., Lewis, K.E. (2024) Transcriptional regulators with broad expression in the zebrafish spinal cord. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(11):1036-1055
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Kröll-Hermi, A., Ebstein, F., Stoetzel, C., Geoffroy, V., Schaefer, E., Scheidecker, S., Bär, S., Takamiya, M., Kawakami, K., Zieba, B.A., Studer, F., Pelletier, V., Eyermann, C., Speeg-Schatz, C., Laugel, V., Lipsker, D., Sandron, F., McGinn, S., Boland, A., Deleuze, J.F., Kuhn, L., Chicher, J., Hammann, P., Friant, S., Etard, C., Krüger, E., Muller, J., Strähle, U., Dollfus, H. (2020) Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress. EMBO Molecular Medicine. 12(7):e11861
- Cheng, Y.C., Huang, Y.C., Yeh, T.H., Shih, H.Y., Lin, C.Y., Lin, S.J., Chiu, C.C., Huang, C.W., Jiang, Y.J. (2015) Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Neural Development. 10:28
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cheng, Y.C., Hsieh, F.Y., Chiang, M.C., Scotting, P.J., Shih, H.Y., Lin, S.J., Wu, H.L., and Lee, H.T. (2013) Akt1 Mediates Neuronal Differentiation in Zebrafish via a Reciprocal Interaction with Notch Signaling. PLoS One. 8(1):e54262
- Long, Y., Song, G., Yan, J., He, X., Li, Q., and Cui, Z. (2013) Transcriptomic characterization of cold acclimation in larval zebrafish. BMC Genomics. 14(1):612
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