Gene
otop1
- ID
- ZDB-GENE-030131-1613
- Name
- otopetrin 1
- Symbol
- otop1 Nomenclature History
- Previous Names
-
- backstroke
- bks
- wu:fb76b02 (1)
- zgc:103626
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables cholesterol binding activity; identical protein binding activity; and proton channel activity. Involved in proton transmembrane transport. Acts upstream of or within otolith formation and otolith mineralization. Is active in membrane. Is expressed in lateral line system; otic vesicle; vestibuloauditory system; and yolk syncytial layer. Orthologous to human OTOP1 (otopetrin 1).
- Genome Resources
-
- Alliance (1)
- Gene:322893 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103626 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-otop1 | Zebrafish Nomenclature Committee | |
CRISPR2-otop1 | Zebrafish Nomenclature Committee | |
CRISPR3-otop1 | Zebrafish Nomenclature Committee | |
MO1-otop1 | N/A | (3) |
MO2-otop1 | N/A | (2) |
MO3-otop1 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR004878 | Otopetrin |
1 - 1 of 1
Domain Details Per Protein
Protein | Additional Resources | Length | Otopetrin |
---|---|---|---|
UniProtKB:Q7ZWK8 | InterPro | 586 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Encodes | EST | fb76b02 | ||
Encodes | cDNA | MGC:103626 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191835 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_198803 (1) | 2150 nt | ||
Genomic | GenBank:CABZ01086808 (1) | 5616 nt | ||
Polypeptide | UniProtKB:Q7ZWK8 (2) | 586 aa |
- Comparative Orthology
- Alliance
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Kröll-Hermi, A., Ebstein, F., Stoetzel, C., Geoffroy, V., Schaefer, E., Scheidecker, S., Bär, S., Takamiya, M., Kawakami, K., Zieba, B.A., Studer, F., Pelletier, V., Eyermann, C., Speeg-Schatz, C., Laugel, V., Lipsker, D., Sandron, F., McGinn, S., Boland, A., Deleuze, J.F., Kuhn, L., Chicher, J., Hammann, P., Friant, S., Etard, C., Krüger, E., Muller, J., Strähle, U., Dollfus, H. (2020) Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress. EMBO Molecular Medicine. 12(7):e11861
- Han, J., Liu, K., Wang, R., Zhang, Y., Zhou, B. (2019) Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 214:105236
- Saotome, K., Teng, B., Tsui, C.C.A., Lee, W.H., Tu, Y.H., Kaplan, J.P., Sansom, M.S.P., Liman, E.R., Ward, A.B. (2019) Structures of the otopetrin proton channels Otop1 and Otop3. Nature structural & molecular biology. 26(6):518-525
- Hu, Z.Y., Zhang, Q.Y., Qin, W., Tong, J.W., Zhao, Q., Han, Y., Meng, J., and Zhang, J.P. (2013) Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish. Cell Death & Disease. 4:e900
- Yu, X., Lau, D., Ng, C.P., and Roy, S. (2011) Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear. Development (Cambridge, England). 138(3):487-494
- Hong, S.K., Levin, C.S., Brown, J.L., Wan, H., Sherman, B.T., Huang, D.W., Lempicki, R.A., and Feldman, B. (2010) Pre-gastrula expression of zebrafish extraembryonic genes. BMC Developmental Biology. 10:42
- Anken, R., Ibsch, M., Kniesel, U., and Rahmann, H. (2004) No correlation between multilamellar bodies in the inner ear and further organs of mutant (backstroke, bks) and wildtype zebrafish embryos. Advances in space research : the official journal of the Committee on Space Research (COSPAR). 33(8):1411-1415
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